Seroatlas · Human Serome Atlas

FER1L5

Fer-1-like protein 5

Also known as: DKFZp434I0121, FR1L5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0AVI2
Gene: FER1L5
Ensembl: ENSG00000249715
Chromosome: 2
Canonical length: 2057 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Predicted to be located in plasma membrane. Predicted to be active in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2057 residues, UniProt reviewed canonical sequence.

>A0AVI2|FER1L5
     1  MLRLVVQSAK IDPPLAPLPR PCMSIDFRDI KKRTRVVEGN DPVWNETLIW HLWNRPLEND
    61  SFLQVTLQDM GSQKKERFIG LATVLLKPLL KQPSEVLFVK DLTLLNHSMK PTDCTVTLQV
   121  AHMSNQDIEK TGAEDHLGIT AREAASQKLM VPGSTAHRAL SSKPQHFQVR VKVFEARQLM
   181  GNNIKPVVKV SIAGQQHQTR IKMGNNPFFN EIFFQNFHEV PAKFFDETIL IQVVNSSAMR
   241  YKAEIGRFQT DIGFIYHSPG HTLLRKWLGL CQPNNPGSGV TGYLKVTIYA LGVGDQALID
   301  QKLLYGTDDT DIQIFKSAVV PINMAYLQLF IYCAEDLHLK KHQSVNPQLE VELIGEKLRT
   361  HMQTQTDNPI WNQILTFRIQ LPCLSSYIKF RVLDCRKKDC PDEIGTASLS LNQISSTGEE
   421  IEGVYSGFLP CFGPSFLTLH GGKKAPFRIQ EEGACIPDSV RDGLAYRGRV FLELITQIKS
   481  YQDSTIKDLS HEVTRIEKHQ NRQKYGLCVI FLSCTMMPNF KELIHFEVSI GHYGNKMDLN
   541  YKPLVSSTPY SPVIYDGNIY HYVPWYNTKP VVAVTSNWED VSFRMNCLNL LHFTRDRLKA
   601  NLDTLKSTRN PKDPALLYQW EKLLRELAED CKRPLPCMTY QPKATSLDRK RWQLRSLLLQ
   661  ELAQKAKQAK PKDMVATAED WLYRLNTVLP EPQMGLPDVM IWLVAKEQRV AYAQVPAHSV
   721  LFSPAGALHS GRLCGKIQTL FLQYPEGEGQ KDVLPAHLRV CMWLGNVTDS KDLQLLRQGD
   781  TAVYAEMYEN QAKYKDQWGQ QGLYHCPNFS DVMGNKTLPM TDFQPPLGWH WQDSWTVEPQ
   841  RRLLLDIDIN KSQVLEEVYE NQGRDTRGAW GPAAIPNTDV NGQPMEAREN VKCPQGWHFK
   901  KDWVVELNHA VDSKGWEYGV GIPPSGLPQV WSPVEKTYHS CRRRRWARVR FRNHGELSHE
   961  QETLSFLQLG LAKGEEEGWE YDTFGSKFHL NPQPQSRFRR RCWRRRLAPN KDKGIAPIFL
  1021  LEGSLAMDLK YHAGKEEDSK TWPWGLDRQF RDPQRQDTRP PNLPFIYCTF NKPHYYQLFC
  1081  YIYQARNLVS NQILTFQGPF IRVVFLNHSQ CTQTLRSSAG PTWAQTLIFQ HLLLYENPQD
  1141  TKESPPLVVL ELWQRDFWGK ESLWGRSVWP PMVWLDLQDR ILPPMRWHPL VKELGKEEGE
  1201  ILASCELILQ TEKLGEKQLP ILSVPWKNGA YTLPKSIQPT IKRMAIEILA WGLRNMKKAS
  1261  SPQLLVEFGE ESLRTEPIRD FQTNPNFPES ESVLVLTVLM PTEEAYALPL VVKVVDNWAF
  1321  GQQTVTGQAN IDFLQPYFCD PWAQDYMHPK LPTLSEKKHQ DFLGYLYRKF WFKSSKAEDE
  1381  YEHEVDWWSK LFWATDEHKS LKYKYKDYHT LKVYECELEA VPAFQGLQDF CQTFKLYQEQ
  1441  PKLDSPVVGE FKGLFRIYPF PENPEAPKPP LQFLVWPERE DFPQPCLVRV YMVRAINLQP
  1501  QDYNGLCDPY VILKLGKTEL GNRDMYQPNT LDPIFGMMFE LTCNIPLEKD LEIQLYDFDL
  1561  FSPDDKIGTT VIDLENRLLS GFGAHCGLSK SYCQSGPFRW RDQMPPSYLL ERYAKRKGLP
  1621  PPLFSPEEDA VFYNGKKFKL QSFEPKTPTV HGLGPKKERL ALYLLHTQGL VPEHVETRTL
  1681  YSHSQPGIDQ GKVQMWVDIF PKKLGPPGPQ VNINPRKPKR YELRCIIWKT ANVDLVDDNL
  1741  SREKTSDIYI KGWLYGLEKD MQKTDIHYHS LTGEADFNWR FIFTMDYLAA ERTCVQSQKD
  1801  YIWSLDATSM KFPARLIIQV WDNDIFSPDD FLGVLELDLS DMPLPARHAK QCSIRMMDAD
  1861  PKWPYFIQYK HFSLFKKKTV TGWWPCQVLD GGKWRLSGKV KMSLEILSEK EALIKPAGRG
  1921  QSEPNQYPTL HPPLRTNTSF TWLRSPVQNF CYIFWKRYRF KLIAFMVISI IALMLFNFIY
  1981  SAPHYLAMSW IKPQLQLYPP IKIFNIINSL NTSNASSSIL PTQDPNLKPT IDHEWKLHPG
  2041  PTNHLSDIFP ELPAPGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FER1L5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 4 nTPM

Expression across tissuesHPA

Tissue

testis: 4 nTPM
choroid plexus: 1 nTPM
pancreas: 0.7 nTPM
epididymis: 0.4 nTPM
breast: 0.3 nTPM
pituitary gland: 0.3 nTPM

Single-cell type

early spermatids: 103 nCPM
late primary spermatocytes: 62 nCPM
pituicytes/fscs: 33 nCPM
choroid plexus epithelial cells: 28 nCPM
ependymal cells: 27 nCPM
renal collecting duct principal cells: 20 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 4.4 nTPM
basal ganglia: 2.6 nTPM
midbrain: 2.3 nTPM
cerebellum: 1.7 nTPM
hippocampal formation: 1.6 nTPM
hypothalamus: 1.5 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

binding of sperm to zona pellucida
myoblast fusion
plasma membrane repair
regulation of neurotransmitter secretion
membrane fusion involved in acrosome reaction

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FER1L5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FER1L5 as an antibody target. Whether an autoantibody or antibody against FER1L5 could matter depends on whether native FER1L5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FER1L5 is annotated at the cell surface, where native FER1L5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FER1L5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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