Seroatlas · Human Serome Atlas

RAB11FIP5

Rab11 family-interacting protein 5

Also known as: GAF1, KIAA0857, pp75, RFIP5_HUMAN, RIP11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXF6
Gene
RAB11FIP5
Ensembl
ENSG00000135631
Chromosome
2
Canonical length
653 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Primary cilium,Centriolar satellite,Basal body,Acrosome,Principal piece,End piece,Annulus

OverviewNCBI Gene

Enables gamma-tubulin binding activity. Involved in cellular response to acidic pH; negative regulation of adiponectin secretion; and regulation of protein localization to cell surface. Located in several cellular components, including microtubule organizing center; mitochondrial outer membrane; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

653 residues, UniProt reviewed canonical sequence.

>Q9BXF6|RAB11FIP5
     1  MALVRGAEPA AGPSRWLPTH VQVTVLRARG LRGKSSGAGS TSDAYTVIQV GREKYSTSVV
    61  EKTHGCPEWR EECSFELPPG ALDGLLRAQE ADAGPAPWAA SSAAACELVL TTMHRSLIGV
   121  DKFLGQATVA LDEVFGAGRA QHTQWYKLHS KPGKKEKERG EIEVTIQFTR NNLSASMFDL
   181  SMKDKPRSPF SKIRDKMKGK KKYDLESASA ILPSSAIEDP DLGSLGKMGK AKGFFLRNKL
   241  RKSSLTQSNT SLGSDSTLSS ASGSLAYQGP GAELLTRSPS RSSWLSTEGG RDSAQSPKLF
   301  THKRTYSDEA NQMRVAPPRA LLDLQGHLDA ASRSSLCVNG SHIYNEEPQG PVRHRSSISG
   361  SLPSSGSLQA VSSRFSEEGP RSTDDTWPRG SRSNSSSEAV LGQEELSAQA KVLAPGASHP
   421  GEEEGARLPE GKPVQVATPI VASSEAVAEK EGARKEERKP RMGLFHHHHQ GLSRSELGRR
   481  SSLGEKGGPI LGASPHHSSS GEEKAKSSWF GLREAKDPTQ KPSPHPVKPL SAAPVEGSPD
   541  RKQSRSSLSI ALSSGLEKLK TVTSGSIQPV TQAPQAGQMV DTKRLKDSAV LDQSAKYYHL
   601  THDELISLLL QRERELSQRD EHVQELESYI DRLLVRIMET SPTLLQIPPG PPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB11FIP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • testis: 35 nTPM
  • spleen: 14 nTPM
  • parathyroid gland: 11 nTPM
  • cerebral cortex: 10 nTPM
  • skeletal muscle: 10 nTPM
  • blood vessel: 9.7 nTPM

Single-cell type

  • retinal ganglion cells: 58 nCPM
  • renal connecting tubule cells: 49 nCPM
  • distal convoluted tubule cells: 40 nCPM
  • proximal tubule cells: 34 nCPM
  • lymphatic endothelial cells: 25 nCPM
  • late primary spermatocytes: 23 nCPM

Immune cell

  • gdT-cell: 0.5 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • T-reg: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 73 nTPM
  • pons: 68 nTPM
  • medulla oblongata: 57 nTPM
  • thalamus: 57 nTPM
  • hypothalamus: 46 nTPM
  • white matter: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
0.7
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB11FIP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB11FIP5 as an antibody target. Whether an autoantibody or antibody against RAB11FIP5 could matter depends on whether native RAB11FIP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB11FIP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB11FIP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB11FIP5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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