Seroatlas · Human Serome Atlas

SYT16

Synaptotagmin-16

Also known as: CHR14SYT, Strep14, SYT14L, SYT16_HUMAN, yt14r

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RD7
Gene: SYT16
Ensembl: ENSG00000139973
Chromosome: 14
Canonical length: 645 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable phospholipid binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

645 residues, UniProt reviewed canonical sequence.

>Q17RD7|SYT16
     1  MVLAMASQDV QNFFQPFSSW ISRVYEALQQ AGDMLSASLV NISKQDSKLS DKLDQDLDNI
    61  QIQETYFEDE EQDNDWSQED ANSLFLEVDH FSCCNSDLQD SAQNSSPSLS QHAKDSCSTM
   121  SQWPNWASDD RKLPHVLSSI AEEEHHLEKQ RSGLQHGFDS QLPGTLETVN GKKQVNSFGD
   181  DEELSTSSDS DEEVIKQFEI SVSRSQSFRS VTSEKGKQTG LEQKPKFSRS LLTHGEDGTE
   241  VSACEDLDGA SQRRYSENLS YGEDDHIPAH SQSPCERGDA KHHGTSHQES SVVQSLRRQS
   301  TEGSLEMETA FNSRGFEDSY ATDSSSMWSP EEQDRTNLQV PSGVSEPISK CGDLDVIFEY
   361  RAASQKLTVT IVRAQGLPDK DRSGVNSWQV HVVLLPGKKH RGRTNIQRGP NPVFREKVTF
   421  AKLEPRDVAA CAVRFRLYAA RKMTRERMMG EKLFYLSHLH PEGEMKVTLV LEPRSNISSG
   481  GSPLSPSAVS HSDSTSSTQS LSHGGAPELL VGLSYNATTG RLSVEMIKGS HFRNLAVNRA
   541  PDTYGKLFLL NSVGQEMSRC KTSIRRGQPN PVYKETFVFQ VALFQLSDVT LMISVYNRRT
   601  MKRKEMIGWI ALGQNSSGEE EQDHWEEMKE TKGQQICRWH TLLES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 9.3 nTPM
basal ganglia: 5.2 nTPM
amygdala: 3.3 nTPM
hippocampal formation: 3.3 nTPM
hypothalamus: 3.3 nTPM
testis: 2.8 nTPM

Single-cell type

brain inhibitory neurons: 293 nCPM
early spermatids: 238 nCPM
brain excitatory neurons: 225 nCPM
oligodendrocyte progenitor cells: 204 nCPM
other brain neurons: 181 nCPM
ependymal cells: 114 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 55 nTPM
basal ganglia: 47 nTPM
hypothalamus: 42 nTPM
hippocampal formation: 39 nTPM
amygdala: 27 nTPM
white matter: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

InteractionsUniProt · HPA

Protein binding partners of SYT16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT16 as an antibody target. Whether an autoantibody or antibody against SYT16 could matter depends on whether native SYT16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYT16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...