ESYT3

Protein identityUniProt · HPA

UniProt accession

A0FGR9

Gene

ESYT3

Ensembl

ENSG00000158220

Chromosome

3

Canonical length

886 aa

Protein class

Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Located in cytoplasmic side of plasma membrane; endoplasmic reticulum membrane; and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

886 residues, UniProt reviewed canonical sequence.

>A0FGR9|ESYT3
     1  MRAEEPCAPG APSALGAQRT PGPELRLSSQ LLPELCTFVV RVLFYLGPVY LAGYLGLSIT
    61  WLLLGALLWM WWRRNRRGKL GRLAAAFEFL DNEREFISRE LRGQHLPAWI HFPDVERVEW
   121  ANKIISQTWP YLSMIMESKF REKLEPKIRE KSIHLRTFTF TKLYFGQKCP RVNGVKAHTN
   181  TCNRRRVTVD LQICYIGDCE ISVELQKIQA GVNGIQLQGT LRVILEPLLV DKPFVGAVTV
   241  FFLQKPHLQI NWTGLTNLLD APGINDVSDS LLEDLIATHL VLPNRVTVPV KKGLDLTNLR
   301  FPLPCGVIRV HLLEAEQLAQ KDNFLGLRGK SDPYAKVSIG LQHFRSRTIY RNLNPTWNEV
   361  FEFMVYEVPG QDLEVDLYDE DTDRDDFLGS LQICLGDVMT NRVVDEWFVL NDTTSGRLHL
   421  RLEWLSLLTD QEVLTEDHGG LSTAILVVFL ESACNLPRNP FDYLNGEYRA KKLSRFARNK
   481  VSKDPSSYVK LSVGKKTHTS KTCPHNKDPV WSQVFSFFVH NVATERLHLK VLDDDQECAL
   541  GMLEVPLCQI LPYADLTLEQ RFQLDHSGLD SLISMRLVLR FLQVEERELG SPYTGPEALK
   601  KGPLLIKKVA TNQGPKAQPQ EEGPTDLPCP PDPASDTKDV SRSTTTTTSA TTVATEPTSQ
   661  ETGPEPKGKD SAKRFCEPIG EKKSPATIFL TVPGPHSPGP IKSPRPMKCP ASPFAWPPKR
   721  LAPSMSSLNS LASSCFDLAD ISLNIEGGDL RRRQLGEIQL TVRYVCLRRC LSVLINGCRN
   781  LTPCTSSGAD PYVRVYLLPE RKWACRKKTS VKRKTLEPLF DETFEFFVPM EEVKKRSLDV
   841  AVKNSRPLGS HRRKELGKVL IDLSKEDLIK GFSQWYELTP NGQPRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ESYT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

6.1 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.11

gnomAD pLI

0

gnomAD missense Z

0.07

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• endoplasmic reticulum-plasma membrane tethering
• lipid transport

Molecular functions

• calcium ion binding
• calcium-dependent phospholipid binding
• phosphatidylcholine binding
• phosphatidylethanolamine binding
• phosphatidylinositol binding

Cellular components

• cytoplasmic side of plasma membrane
• endoplasmic reticulum membrane
• endoplasmic reticulum-plasma membrane contact site
• organelle membrane contact site
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• C2 domain
• Synaptotagmin-like mitochondrial-lipid-binding domain
• C2 domain superfamily
• Extended synaptotagmin, C2A domain
• Extended synaptotagmin, C2B domain
• Extended synaptotagmin, C-terminal C2 domain
• Synaptotagmin, SMP domain
• Extended Synaptotagmin
• C2 domain
• Synaptotagmin-like mitochondrial-lipid-binding domain

KeywordsUniProt

• Calcium
• Cell membrane
• Endoplasmic reticulum
• Lipid transport
• Lipid-binding
• Membrane
• Metal-binding
• Repeat
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of ESYT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ESYT1
• ESYT2