Seroatlas · Human Serome Atlas

RAB11FIP2

Rab11 family-interacting protein 2

Also known as: KIAA0941, nRip11, Rab11-FIP2, RFIP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L804
Gene
RAB11FIP2
Ensembl
ENSG00000107560
Chromosome
10
Canonical length
512 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables protein homodimerization activity and protein kinase binding activity. Involved in several processes, including TRAM-dependent toll-like receptor 4 signaling pathway; phagocytosis; and positive regulation of GTPase activity. Located in endosome; nucleoplasm; and phagocytic cup. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>Q7L804|RAB11FIP2
     1  MMLSEQAQKW FPTHVQVTVL QAKDLKPKGK SGTNDTYTII QLGKEKYSTS VAEKTLEPVW
    61  KEEASFELPG LLIQGSPEKY ILFLIVMHRS LVGLDKFLGQ VAINLNDIFE DKQRRKTEWF
   121  RLESKQGKRI KNRGEIKVNI QFMRNNMTAS MFDLSMKDKT RSPFAKLKDK MKGRKNDGTF
   181  SDTSSAIIPS THMPDANSEF SSGEIQMKSK PKKPFLLGPQ RLSSAHSMSD LSGSHMSSEK
   241  LKAGTIGQTH LLGHQLDSFG TVPESGSLKS PHRRTLSFDT SKMNQPDSIV DEGELCFGRQ
   301  NDPFTNVTAS LPQKFATLPR KKNPFEESSE TWDSSMNLFS KPIEIRKENK REKREKVSLF
   361  ERVTGKKDSR RSDKLNNGGS DSPCDLKSPN AFSENRQDYF DYESTNPFTA KFRASNIMPS
   421  SSFHMSPTSN EDLRKIPDSN PFDATAGYRS LTYEEVLQEL VKHKELLRRK DTHIRELEDY
   481  IDNLLVRVME ETPSILRVPY EPSRKAGKFS NS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB11FIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 27 nTPM
  • seminal vesicle: 23 nTPM
  • smooth muscle: 18 nTPM
  • endometrium: 18 nTPM
  • stomach: 16 nTPM
  • bone marrow: 13 nTPM

Single-cell type

  • parietal cells: 327 nCPM
  • epididymal efferent duct absorptive cells: 229 nCPM
  • renal collecting duct principal cells: 201 nCPM
  • neutrophil progenitors: 182 nCPM
  • renal connecting tubule cells: 169 nCPM
  • epididymal basal cells: 149 nCPM

Immune cell

  • plasmacytoid DC: 0.5 nTPM
  • naive B-cell: 0.4 nTPM
  • naive CD4 T-cell: 0.4 nTPM
  • memory B-cell: 0.3 nTPM
  • neutrophil: 0.3 nTPM
  • basophil: 0.2 nTPM

Brain region

  • cerebral cortex: 25 nTPM
  • basal ganglia: 24 nTPM
  • hippocampal formation: 22 nTPM
  • white matter: 21 nTPM
  • thalamus: 20 nTPM
  • amygdala: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.94
gnomAD missense Z
0.78
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB11FIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB11FIP2 as an antibody target. Whether an autoantibody or antibody against RAB11FIP2 could matter depends on whether native RAB11FIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB11FIP2 is annotated at the cell surface, where native RAB11FIP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAB11FIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAB11FIP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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