Seroatlas · Human Serome Atlas

WWP2

NEDD4-like E3 ubiquitin-protein ligase WWP2

Also known as: AIP2, WWP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00308
Gene: WWP2
Ensembl: ENSG00000198373
Chromosome: 16
Canonical length: 870 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

870 residues, UniProt reviewed canonical sequence.

>O00308|WWP2
     1  MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI
    61  GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENMQLT
   121  LNLQTENKGS VVSGGELTIF LDGPTVDLGN VPNGSALTDG SQLPSRDSSG TAVAPENRHQ
   181  PPSTNCFGGR SRTHRHSGAS ARTTPATGEQ SPGARSRHRQ PVKNSGHSGL ANGTVNDEPT
   241  TATDPEEPSV VGVTSPPAAP LSVTPNPNTT SLPAPATPAE GEEPSTSGTQ QLPAAAQAPD
   301  ALPAGWEQRE LPNGRVYYVD HNTKTTTWER PLPPGWEKRT DPRGRFYYVD HNTRTTTWQR
   361  PTAEYVRNYE QWQSQRNQLQ GAMQHFSQRF LYQSSSASTD HDPLGPLPPG WEKRQDNGRV
   421  YYVNHNTRTT QWEDPRTQGM IQEPALPPGW EMKYTSEGVR YFVDHNTRTT TFKDPRPGFE
   481  SGTKQGSPGA YDRSFRWKYH QFRFLCHSNA LPSHVKISVS RQTLFEDSFQ QIMNMKPYDL
   541  RRRLYIIMRG EEGLDYGGIA REWFFLLSHE VLNPMYCLFE YAGKNNYCLQ INPASSINPD
   601  HLTYFRFIGR FIAMALYHGK FIDTGFTLPF YKRMLNKRPT LKDLESIDPE FYNSIVWIKE
   661  NNLEECGLEL YFIQDMEILG KVTTHELKEG GESIRVTEEN KEEYIMLLTD WRFTRGVEEQ
   721  TKAFLDGFNE VAPLEWLRYF DEKELELMLC GMQEIDMSDW QKSTIYRHYT KNSKQIQWFW
   781  QVVKEMDNEK RIRLLQFVTG TCRLPVGGFA ELIGSNGPQK FCIDKVGKET WLPRSHTCFN
   841  RLDLPPYKSY EQLREKLLYA IEETEGFGQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WWP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 112 nTPM
kidney: 33 nTPM
bone marrow: 33 nTPM
salivary gland: 30 nTPM
adrenal gland: 30 nTPM
skin: 29 nTPM

Single-cell type

neutrophils: 748 nCPM
neutrophil progenitors: 340 nCPM
renal collecting duct intercalated cells: 189 nCPM
oligodendrocyte progenitor cells: 187 nCPM
monocytes: 170 nCPM
choroid plexus epithelial cells: 164 nCPM

Immune cell

neutrophil: 50 nTPM
basophil: 36 nTPM
non-classical monocyte: 31 nTPM
eosinophil: 30 nTPM
intermediate monocyte: 24 nTPM
classical monocyte: 19 nTPM

Brain region

white matter: 51 nTPM
choroid plexus: 47 nTPM
cerebral cortex: 46 nTPM
medulla oblongata: 45 nTPM
basal ganglia: 45 nTPM
amygdala: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.16
gnomAD missense Z: 1.59
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WWP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WWP2 as an antibody target. Whether an autoantibody or antibody against WWP2 could matter depends on whether native WWP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WWP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WWP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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