Seroatlas · Human Serome Atlas

CPNE3

Copine-3

Also known as: CPNE3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75131
Gene
CPNE3
Ensembl
ENSG00000085719
Chromosome
8
Canonical length
537 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

537 residues, UniProt reviewed canonical sequence.

>O75131|CPNE3
     1  MAAQCVTKVA LNVSCANLLD KDIGSKSDPL CVLFLNTSGQ QWYEVERTER IKNCLNPQFS
    61  KTFIIDYYFE VVQKLKFGVY DIDNKTIELS DDDFLGECEC TLGQIVSSKK LTRPLVMKTG
   121  RPAGKGSITI SAEEIKDNRV VLFEMEARKL DNKDLFGKSD PYLEFHKQTS DGNWLMVHRT
   181  EVVKNNLNPV WRPFKISLNS LCYGDMDKTI KVECYDYDND GSHDLIGTFQ TTMTKLKEAS
   241  RSSPVEFECI NEKKRQKKKS YKNSGVISVK QCEITVECTF LDYIMGGCQL NFTVGVDFTG
   301  SNGDPRSPDS LHYISPNGVN EYLTALWSVG LVIQDYDADK MFPAFGFGAQ IPPQWQVSHE
   361  FPMNFNPSNP YCNGIQGIVE AYRSCLPQIK LYGPTNFSPI INHVARFAAA ATQQQTASQY
   421  FVLLIITDGV ITDLDETRQA IVNASRLPMS IIIVGVGGAD FSAMEFLDGD GGSLRSPLGE
   481  VAIRDIVQFV PFRQFQNAPK EALAQCVLAE IPQQVVGYFN TYKLLPPKNP ATKQQKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPNE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 72 nTPM
  • esophagus: 69 nTPM
  • thyroid gland: 57 nTPM
  • heart muscle: 49 nTPM
  • parathyroid gland: 49 nTPM
  • kidney: 48 nTPM

Single-cell type

  • esophageal apical cells: 1,102 nCPM
  • neutrophil progenitors: 969 nCPM
  • esophageal suprabasal cells: 420 nCPM
  • esophageal basal cells: 211 nCPM
  • suprabasal keratinocytes: 206 nCPM
  • neutrophils: 165 nCPM

Immune cell

  • myeloid DC: 63 nTPM
  • plasmacytoid DC: 62 nTPM
  • eosinophil: 53 nTPM
  • non-classical monocyte: 53 nTPM
  • neutrophil: 46 nTPM
  • intermediate monocyte: 38 nTPM

Brain region

  • choroid plexus: 67 nTPM
  • cerebellum: 63 nTPM
  • white matter: 58 nTPM
  • hypothalamus: 56 nTPM
  • midbrain: 53 nTPM
  • medulla oblongata: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0
gnomAD missense Z
-0.98
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CPNE3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPNE3 as an antibody target. Whether an autoantibody or antibody against CPNE3 could matter depends on whether native CPNE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPNE3 is annotated at the cell surface, where native CPNE3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPNE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPNE3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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