Seroatlas · Human Serome Atlas

C2CD2L

Phospholipid transfer protein C2CD2L

Also known as: C2C2L_HUMAN, KIAA0285, TMEM24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14523
Gene
C2CD2L
Ensembl
ENSG00000172375
Chromosome
11
Canonical length
706 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables phosphatidylinositol binding activity and phosphatidylinositol transfer activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in cortical endoplasmic reticulum; cytoplasmic side of apical plasma membrane; and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

706 residues, UniProt reviewed canonical sequence.

>O14523|C2CD2L
     1  MDPGWGQRDV GWAALLILFA ASLLTVFAWL LQYARGLWLA RARGDRGPGP ALAGEPAGSL
    61  RELGVWRSLL RLRATRAGAA EEPGVRGLLA SLFAFKSFRE NWQRAWVRAL NEQACRNGSS
   121  IQIAFEEVPQ LPPRASISHV TCVDQSEHTM VLRCQLSAEE VRFPVSVTQQ SPAAVSMETY
   181  HVTLTLPPTQ LEVNLEEIPG EGLLISWAFT DRPDLSLTVL PKLQARERGE EQVELSTIEE
   241  LIKDAIVSTQ PAMMVNLRAC SAPGGLVPSE KPPMMPQAQP AIPRPNRLFL RQLRASHLGN
   301  ELEGTEELCC VAELDNPMQQ KWTKPARAGS EVEWTEDLAL DLGPQSRELT LKVLRSSSCG
   361  DTELLGQATL PVGSPSRPLS RRQLCPLTPG PGKALGPAAT MAVELHYEEG SPRNLGTPTS
   421  STPRPSITPT KKIELDRTIM PDGTIVTTVT TVQSRPRIDG KLDSPSRSPS KVEVTEKTTT
   481  VLSESSGPSN TSHSSSRDSH LSNGLDPVAE TAIRQLTEPS GRVAKKTPTK RSTLIISGVS
   541  KVPIAQDELA LSLGYAASLE ASVQDDAGTS GGPSSPPSDP PAMSPGPLDA LSSPTSVQEA
   601  DETTRSDISE RPSVDDIESE TGSTGALETR SLKDHKVSFL RSGTKLIFRR RPRQKEAGLS
   661  QSHDDLSNAT ATPSVRKKAG SFSRRLIKRF SFKSKPKANG NPSPQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2CD2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 38 nTPM
  • cerebral cortex: 37 nTPM
  • cerebellum: 28 nTPM
  • hippocampal formation: 25 nTPM
  • amygdala: 24 nTPM
  • pituitary gland: 23 nTPM

Single-cell type

  • enterocytes: 33 nCPM
  • colonocytes: 27 nCPM
  • brain inhibitory neurons: 25 nCPM
  • respiratory ciliated cells: 24 nCPM
  • brain excitatory neurons: 19 nCPM
  • other brain neurons: 19 nCPM

Immune cell

  • eosinophil: 2.7 nTPM
  • non-classical monocyte: 2.1 nTPM
  • intermediate monocyte: 1.4 nTPM
  • classical monocyte: 1.3 nTPM
  • NK-cell: 0.8 nTPM
  • T-reg: 0.7 nTPM

Brain region

  • basal ganglia: 43 nTPM
  • cerebral cortex: 42 nTPM
  • amygdala: 42 nTPM
  • hippocampal formation: 39 nTPM
  • white matter: 34 nTPM
  • thalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.99
gnomAD missense Z
1.78
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C2CD2L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2CD2L as an antibody target. Whether an autoantibody or antibody against C2CD2L could matter depends on whether native C2CD2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2CD2L is annotated at the cell surface, where native C2CD2L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label C2CD2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C2CD2L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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