Seroatlas · Human Serome Atlas

C2CD5

C2 domain-containing protein 5

Also known as: C2CD5_HUMAN, CDP138, KIAA0528

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YS7
Gene: C2CD5
Ensembl: ENSG00000111731
Chromosome: 12
Canonical length: 1000 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centriolar satellite,Cytosol

OverviewNCBI Gene

Enables calcium ion binding activity and calcium-dependent phospholipid binding activity. Involved in several processes, including insulin receptor signaling pathway; intracellular protein transmembrane transport; and positive regulation of protein targeting to membrane. Located in several cellular components, including centriolar satellite; cytoplasmic vesicle membrane; and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1000 residues, UniProt reviewed canonical sequence.

>Q86YS7|C2CD5
     1  MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYLKSLNPQ WNSEWFKFEV
    61  DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYSE AATVISGWFP IYDTIHGIRG
   121  EINVVVKVDL FNDLNRFRQS SCGVKFFCTT SIPKCYRAVI IHGFVEELVV NEDPEYQWID
   181  RIRTPRASNE ARQRLISLMS GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG
   241  TACTLDKLSS PAAFLPACNS PSKEMKEIPF NEDPNPNTHS SGPSTPLKNQ TYSFSPSKSY
   301  SRQSSSSDTD LSLTPKTGMG SGSAGKEGGP FKALLRQQTQ SALEQREFPF FTLTAFPPGF
   361  LVHVGGVVSA RSVKLLDRIH NPDEPETRDA WWAEIRQEIK SHAKALGCHA VVGYSESTSI
   421  CEEVCILSAS GTAAVLNPRF LQDGTVEGCL EQRLEENLPT RCGFCHIPYD ELNMPFPAHL
   481  TYCYNCRKQK VPDVLFTTID LPTDATVIGK GCLIQARLCR LKKKAQAEAN ATAISNLLPF
   541  MEYEVHTQLM NKLKLKGMNA LFGLRIQITV GENMLMGLAS ATGVYLAALP TPGGIQIAGK
   601  TPNDGSYEQH ISHMQKKIND TIAKNKELYE INPPEISEEI IGSPIPEPRQ RSRLLRSQSE
   661  SSDEVTELDL SHGKKDAFVL EIDDTDAMED VHSLLTDVPP PSGFYSCNTE IMPGINNWTS
   721  EIQMFTSVRV IRLSSLNLTN QALNKNFNDL CENLLKSLYF KLRSMIPCCL CHVNFTVSLP
   781  EDELIQVTVT AVAITFDKNQ ALQTTKTPVE KSLQRASTDN EELLQFPLEL CSDSLPSHPF
   841  PPAKAMTVEK ASPVGDGNFR NRSAPPCANS TVGVVKMTPL SFIPGAKITK YLGIINMFFI
   901  RETTSLREEG GVSGFLHAFI AEVFAMVRAH VAALGGNAVV SYIMKQCVFM ENPNKNQAQC
   961  LINVSGDAVV FVRESDLEVV SSQQPTTNCQ SSCTEGEVTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2CD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

retina: 52 nTPM
cerebellum: 45 nTPM
rectum: 26 nTPM
parathyroid gland: 25 nTPM
stomach: 25 nTPM
thymus: 25 nTPM

Single-cell type

lactotrophs: 318 nCPM
brain excitatory neurons: 274 nCPM
thyrotrophs: 267 nCPM
brain inhibitory neurons: 263 nCPM
corticotrophs: 219 nCPM
kupffer cells: 203 nCPM

Immune cell

basophil: 23 nTPM
non-classical monocyte: 17 nTPM
intermediate monocyte: 15 nTPM
NK-cell: 14 nTPM
T-reg: 9.1 nTPM
memory CD4 T-cell: 8.4 nTPM

Brain region

cerebellum: 96 nTPM
cerebral cortex: 76 nTPM
white matter: 68 nTPM
basal ganglia: 61 nTPM
pons: 54 nTPM
hippocampal formation: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0
gnomAD missense Z: 2.68
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

C2 domain
C2 domain superfamily
C2 domain
C2CD5, C2 domain
C2 domain-containing protein 5
C2 domain-containing protein 5, forth YbjQ-like domain
C2 domain-containing protein 5, YbjQ-like domain
C2CD5, C-terminal domain
C2 domain-containing protein 5, YbjQ-like domain
C2 domain-containing protein 5, fifth YbjQ-like domain
C2CD5, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C2CD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FIBP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2CD5 as an antibody target. Whether an autoantibody or antibody against C2CD5 could matter depends on whether native C2CD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2CD5 is annotated at the cell surface, where native C2CD5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label C2CD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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