Seroatlas · Human Serome Atlas

RAB11FIP1

Rab11 family-interacting protein 1

Also known as: FLJ22524, FLJ22622, Rab11-FIP1, RCP, RFIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6WKZ4
Gene: RAB11FIP1
Ensembl: ENSG00000156675
Chromosome: 8
Canonical length: 1283 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles
Quaternary structure: Homooligomer

OverviewNCBI Gene

This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

1283 residues, UniProt reviewed canonical sequence.

>Q6WKZ4|RAB11FIP1
     1  MSLMVSAGRG LGAVWSPTHV QVTVLQARGL RAKGPGGTSD AYAVIQVGKE KYATSVSERS
    61  LGAPVWREEA TFELPSLLSS GPAAAATLQL TVLHRALLGL DKFLGRAEVD LRDLHRDQGR
   121  RKTQWYKLKS KPGKKDKERG EIEVDIQFMR NNMTASMFDL SMKDKSRNPF GKLKDKIKGK
   181  NKDSGSDTAS AIIPSTTPSV DSDDESVVKD KKKKSKIKTL LSKSNLQKTP LSQSMSVLPT
   241  SKPEKVLLRP GDFQSQWDED DNEDESSSAS DVMSHKRTAS TDLKQLNQVN FTLPKKEGLS
   301  FLGGLRSKND VLSRSNVCIN GNHVYLEQPE AKGEIKDSSP SSSPSPKGFR KKHLFSSTEN
   361  LAAGSWKEPA EGGGLSSDRQ LSESSTKDSL KSMTLPSYRP APLVSGDLRE NMAPANSEAT
   421  KEAKESKKPE SRRSSLLSLM TGKKDVAKGS EGENPLTVPG REKEGMLMGV KPGEDASGPA
   481  EDLVRRSEKD TAAVVSRQGS SLNLFEDVQI TEPEAEPESK SEPRPPISSP RAPQTRAVKP
   541  RLEVSPEAQP TARLPSPTDS PSSLPPLPSS SGQASVPSEL GHGADTQSSE SPSVFSSLSS
   601  PIAAPISTST PIESWPLVDR GQAKSEGPPL LPKAELQTES LTPVPNSGSS ALGSLFKQPS
   661  FPANKGTEDS LMGRTRETGT EKNTSSLELE ESLPEQPETG RQEEELPRFP CKKQDYSPSS
   721  GEAQEVPFAL SLSSDGAVSP VGELAAGGDR DLESQAGSLV ESKARDAAEE VAPPLPMGAS
   781  VPSIDSMMRK LEEMGLNLRK DQKKTKKRVS FSEQLFTEEA VAGAALLVEG HSSCPQELNP
   841  AWSVAGNASD GEPPESPHAE DSERESVTTP GPATCGAPAS PADHLLLPSQ EESFSEVPMS
   901  EASSAKDTPL FRMEGEDALV TQYQSKASDH EGLLSDPLSD LQLVSDFKSP IMADLNLSLP
   961  SIPEVASDDE RIDQVEDDGD QVEDDGETAK SSTLDIGALS LGLVVPCPER GKGPSGEADR
  1021  LVLGEGLCDF RLQAPQASVT APSEQTTEFG IHKPHLGKSS SLDKQLPGPS GGEEEKPMGN
  1081  GSPSPPPGTS LDNPVPSPSP SEIFPVTHSF PSSAHSDTHH TSTAESQKKA TAEGSAGRVE
  1141  NFGKRKPLLQ AWVSPSETHP VSAQPGAGTG SAKHRLHPVK PMNAMATKVA NCSLGTATII
  1201  SENLNNEVMM KKYSPSDPAF AYAQLTHDEL IQLVLKQKET ISKKEFQVRE LEDYIDNLLV
  1261  RVMEETPNIL RIPTQVGKKA GKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAB11FIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

lung: 70 nTPM
bone marrow: 55 nTPM
small intestine: 50 nTPM
choroid plexus: 45 nTPM
rectum: 44 nTPM
esophagus: 44 nTPM

Single-cell type

alveolar cells type 1: 3,604 nCPM
pancreatic acinar cells: 2,154 nCPM
esophageal apical cells: 2,112 nCPM
endometrial glandular cells: 1,877 nCPM
endometrial luminal cells: 1,716 nCPM
urothelial cells: 1,558 nCPM

Immune cell

neutrophil: 102 nTPM
eosinophil: 38 nTPM
basophil: 24 nTPM
classical monocyte: 21 nTPM
non-classical monocyte: 20 nTPM
myeloid DC: 18 nTPM

Brain region

choroid plexus: 85 nTPM
hippocampal formation: 12 nTPM
hypothalamus: 12 nTPM
amygdala: 11 nTPM
cerebral cortex: 11 nTPM
cerebellum: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.66
DepMap mean gene effect: 0.25
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

small GTPase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAB11FIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAB11FIP1 as an antibody target. Whether an autoantibody or antibody against RAB11FIP1 could matter depends on whether native RAB11FIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAB11FIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAB11FIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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