Seroatlas · Human Serome Atlas

CPNE4

Copine-4

Also known as: COPN4, CPN4, CPNE4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96A23
Gene
CPNE4
Ensembl
ENSG00000196353
Chromosome
3
Canonical length
557 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene belongs to the highly conserved copine family. It encodes a calcium-dependent, phospholipid-binding protein, which may be involved in membrane trafficking, mitogenesis and development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

557 residues, UniProt reviewed canonical sequence.

>Q96A23|CPNE4
     1  MKKMSNIYES AANTLGIFNS PCLTKVELRV ACKGISDRDA LSKPDPCVIL KMQSHGQWFE
    61  VDRTEVIRTC INPVYSKLFT VDFYFEEVQR LRFEVHDISS NHNGLKEADF LGGMECTLGQ
   121  IVSQRKLSKS LLKHGNTAGK SSITVIAEEL SGNDDYVELA FNARKLDDKD FFSKSDPFLE
   181  IFRMNDDATQ QLVHRTEVVM NNLSPAWKSF KVSVNSLCSG DPDRRLKCIV WDWDSNGKHD
   241  FIGEFTSTFK EMRGAMEGKQ VQWECINPKY KAKKKNYKNS GTVILNLCKI HKMHSFLDYI
   301  MGGCQIQFTV AIDFTASNGD PRNSCSLHYI HPYQPNEYLK ALVAVGEICQ DYDSDKMFPA
   361  FGFGARIPPE YTVSHDFAIN FNEDNPECAG IQGVVEAYQS CLPKLQLYGP TNIAPIIQKV
   421  AKSASEETNT KEASQYFILL ILTDGVITDM ADTREAIVHA SHLPMSVIIV GVGNADFSDM
   481  QMLDGDDGIL RSPKGEPVLR DIVQFVPFRN FKHASPAALA KSVLAEVPNQ VVDYYNGKGI
   541  KPKCSSEMYE SSRTLAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPNE4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 25 nTPM
  • cerebral cortex: 8.7 nTPM
  • hippocampal formation: 5 nTPM
  • seminal vesicle: 3.5 nTPM
  • blood vessel: 3.3 nTPM
  • pituitary gland: 2.9 nTPM

Single-cell type

  • prostatic glandular cells: 4,673 nCPM
  • thyrotrophs: 840 nCPM
  • pituitary stem cells: 654 nCPM
  • sertoli cells: 474 nCPM
  • other brain neurons: 313 nCPM
  • brain excitatory neurons: 236 nCPM

Immune cell

  • neutrophil: 0.7 nTPM
  • eosinophil: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 97 nTPM
  • hippocampal formation: 57 nTPM
  • thalamus: 45 nTPM
  • basal ganglia: 32 nTPM
  • white matter: 29 nTPM
  • amygdala: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.09
gnomAD missense Z
2.65
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CPNE4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPNE4 as an antibody target. Whether an autoantibody or antibody against CPNE4 could matter depends on whether native CPNE4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPNE4 is annotated at the cell surface, where native CPNE4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPNE4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPNE4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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