CC2D1B

Protein identityUniProt · HPA

UniProt accession

Q5T0F9

Gene

CC2D1B

Ensembl

ENSG00000154222

Chromosome

1

Canonical length

858 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

858 residues, UniProt reviewed canonical sequence.

>Q5T0F9|CC2D1B
     1  MMPGPRPRKG PQARGQGVAA AKQMGLFMEF GPEDMLLGMD EAEDDEDLEA ELLALTGEAQ
    61  TTGKKPAPKG QAPLPMAHIE KLAADCMRDV EEEEEEEGLE EDAELLTELQ EVLGVDEETE
   121  PLDGDEVADP GGSEEENGLE DTEPPVQTAV LTASAPAAQA GASQGLHALL EERIHNYREA
   181  AASAKEAGEA AKARRCERGL KTLESQLASV RRGRKINEDE IPPPVALGKR PLAPQEPANR
   241  SPETDPPAPP ALESDNPSQP ETSLPGISAQ PVSDLDPDPR ALLSSRQREY KVAALSAKRA
   301  GELDRARELM RIGKRFGAVL EALEKGQPVD LSAMPPAPED LKPQQASQAP TAPSVIPPAV
   361  ERVQPVMAPD VPATPVAPTE SQTVLDALQQ RLNKYREAGI QARSGGDERK ARMHERIAKQ
   421  YQDAIRAHRA GRKVNFAELP VPPGFPPIPG LESTMGVEED AVAATLAAAE KLASAEDSAP
   481  ADKDEDEPPG HLQGEPPAQA PVAKKPARPT VPSSQRLPEP RASSSKESPS PSVREQLALL
   541  EARKLQYQRA ALQAKRSQDL EQAKAYLRVA KWLEAQIIQA RSGRPVDLSK VPSPLTDEEG
   601  DFILIHHEDL RLSQKAEEVY AQLQKMLLEQ QEKCLLFSKQ FMHQGNVAET TRFEKLAQDR
   661  KKQLEILQLA QAQGLDPPTH HFELKTFQTV RIFSELNSTE MHLIIVRGMN LPAPPGVTPD
   721  DLDAFVRFEF HYPNSDQAQK SKTAVVKNTN SPEFDQLFKL NINRNHRGFK RVIQSKGIKF
   781  EIFHKGSFFR SDKLVGTAHL KLERLENECE IREIVEVLDG RKPTGGKLEV KVRLREPLSG
   841  QDVQMVTENW LVLEPRGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CC2D1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

30 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.92

gnomAD pLI

0

gnomAD missense Z

-1.01

DepMap mean gene effect

-0.21

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• DNA-binding transcription repressor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding

Cellular components

• cytosol
• endosome membrane
• nuclear envelope
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• C2 domain
• Coiled-coil and C2 domain-containing protein 1, DM14 domain
• C2 domain superfamily
• Freud, C2 domain
• Coiled-coil and C2 domain-containing protein 1
• C2 domain
• Coiled-coil and C2 domain-containing protein 1, DM14 domain

KeywordsUniProt

• Coiled coil
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of CC2D1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CHMP4B