Seroatlas · Human Serome Atlas

CADPS

Calcium-dependent secretion activator 1

Also known as: CAPS, CAPS1, CAPS1_HUMAN, KIAA1121, UNC-31

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULU8
Gene: CADPS
Ensembl: ENSG00000163618
Chromosome: 3
Canonical length: 1353 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

1353 residues, UniProt reviewed canonical sequence.

>Q9ULU8|CADPS
     1  MLDPSSSEEE SDEIVEEESG KEVLGSAPSG ARLSPSRTSE GSAGSAGLGG GGAGAGAGVG
    61  AGGGGGSGAS SGGGAGGLQP SSRAGGGRPS SPSPSVVSEK EKEELERLQK EEEERKKRLQ
   121  LYVFVMRCIA YPFNAKQPTD MARRQQKISK QQLQTVKDRF QAFLNGETQI MADEAFMNAV
   181  QSYYEVFLKS DRVARMVQSG GCSANDSREV FKKHIEKRVR SLPEIDGLSK ETVLSSWMAK
   241  FDAIYRGEED PRKQQARMTA SAASELILSK EQLYEMFQNI LGIKKFEHQL LYNACQLDNP
   301  DEQAAQIRRE LDGRLQMADQ IARERKFPKF VSKEMENMYI EELKSSVNLL MANLESMPVS
   361  KGGEFKLQKL KRSHNASIID MGEESENQLS KSDVVLSFSL EVVIMEVQGL KSLAPNRIVY
   421  CTMEVEGGEK LQTDQAEASK PTWGTQGDFS TTHALPAVKV KLFTESTGVL ALEDKELGRV
   481  ILHPTPNSPK QSEWHKMTVS KNCPDQDLKI KLAVRMDKPQ NMKHSGYLWA IGKNVWKRWK
   541  KRFFVLVQVS QYTFAMCSYR EKKAEPQELL QLDGYTVDYT DPQPGLEGGR AFFNAVKEGD
   601  TVIFASDDEQ DRILWVQAMY RATGQSHKPV PPTQVQKLNA KGGNVPQLDA PISQFYADRA
   661  QKHGMDEFIS SNPCNFDHAS LFEMVQRLTL DHRLNDSYSC LGWFSPGQVF VLDEYCARNG
   721  VRGCHRHLCY LRDLLERAEN GAMIDPTLLH YSFAFCASHV HGNRPDGIGT VTVEEKERFE
   781  EIKERLRVLL ENQITHFRYC FPFGRPEGAL KATLSLLERV LMKDIVTPVP QEEVKTVIRK
   841  CLEQAALVNY SRLSEYAKIE ENQKDAENVG RLITPAKKLE DTIRLAELVI EVLQQNEEHH
   901  AEPHVDKGEA FAWWSDLMVE HAETFLSLFA VDMDAALEVQ PPDTWDSFPL FQLLNDFLRT
   961  DYNLCNGKFH KHLQDLFAPL VVRYVDLMES SIAQSIHRGF ERESWEPVKS LTSNLPNVNL
  1021  PNVNLPKVPN LPVNIPLGIP QMPTFSAPSW MAAIYDADNG SGTSEDLFWK LDALQTFIRD
  1081  LHWPEEEFGK HLEQRLKLMA SDMIESCVKR TRIAFEVKLQ KTSRSTDFRV PQSICTMFNV
  1141  MVDAKAQSTK LCSMEMGQEH QYHSKIDELI EETVKEMITL LVAKFVTILE GVLAKLSRYD
  1201  EGTLFSSFLS FTVKAASKYV DVPKPGMDVA DAYVTFVRHS QDVLRDKVNE EMYIERLFDQ
  1261  WYNSSMNVIC TWLTDRMDLQ LHIYQLKTLI RMVKKTYRDF RLQGVLDSTL NSKTYETIRN
  1321  RLTVEEATAS VSEGGGLQGI SMKDSDEEDE EDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CADPS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 171 nTPM

Expression across tissuesHPA

Tissue

retina: 171 nTPM
cerebral cortex: 77 nTPM
midbrain: 71 nTPM
hypothalamus: 61 nTPM
cerebellum: 54 nTPM
hippocampal formation: 53 nTPM

Single-cell type

somatotrophs: 3,529 nCPM
retinal bipolar cells: 3,076 nCPM
cone photoreceptor cells: 1,569 nCPM
thyrotrophs: 1,525 nCPM
retinal amacrine cells: 1,490 nCPM
adrenal medulla cells: 1,298 nCPM

Immune cell

memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 261 nTPM
cerebral cortex: 260 nTPM
white matter: 210 nTPM
medulla oblongata: 191 nTPM
midbrain: 167 nTPM
thalamus: 155 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0
gnomAD missense Z: 3.1
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CADPS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CADPS as an antibody target. Whether an autoantibody or antibody against CADPS could matter depends on whether native CADPS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CADPS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CADPS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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