Seroatlas · Human Serome Atlas

PLA2G4E

Cytosolic phospholipase A2 epsilon

Also known as: FLJ45651, PA24E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3MJ16
Gene
PLA2G4E
Ensembl
ENSG00000188089
Chromosome
15
Canonical length
868 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

868 residues, UniProt reviewed canonical sequence.

>Q3MJ16|PLA2G4E
     1  MSLQASEGCP GLGTNVFVPQ SPQTDEEGSR SGRSFSEFED TQDLDTPGLP PFCPMAPWGS
    61  EEGLSPCHLL TVRVIRMKNV RQADMLSQTD CFVSLWLPTA SQKKLRTRTI SNCPNPEWNE
   121  SFNFQIQSRV KNVLELSVCD EDTVTPDDHL LTVLYDLTKL CFRKKTHVKF PLNPQGMEEL
   181  EVEFLLEESP SPPETLVTNG VLVSRQVSCL EVHAQSRRRR KREKMKDLLV MVNESFENTQ
   241  RVRPCLEPCC PTSACFQTAA CFHYPKYFQS QVHVEVPKSH WSCGLCCRSR KKGPISQPLD
   301  CLSDGQVMTL PVGESYELHM KSTPCPETLD VRLGFSLCPA ELEFLQKRKV VVAKALKQVL
   361  QLEEDLQEDE VPLIAIMATG GGTRSMTSMY GHLLGLQKLN LLDCASYITG LSGATWTMAT
   421  LYRDPDWSSK NLEPAIFEAR RHVVKDKLPS LFPDQLRKFQ EELRQRSQEG YRVTFTDFWG
   481  LLIETCLGDE RNECKLSDQR AALSCGQNPL PIYLTINVKD DVSNQDFREW FEFSPYEVGL
   541  QKYGAFIPSE LFGSEFFMGR LVKRIPESRI CYMLGLWSSI FSLNLLDAWN LSHTSEEFFH
   601  RWTREKVQDI EDEPILPEIP KCDANILETT VVIPGSWLSN SFREILTHRS FVSEFHNFLS
   661  GLQLHTNYLQ NGQFSRWKDT VLDGFPNQLT ESANHLCLLD TAFFVNSSYP PLLRPERKAD
   721  LIIHLNYCAG SQTKPLKQTC EYCTVQNIPF PKYELPDENE NLKECYLMEN PQEPDAPIVT
   781  FFPLINDTFR KYKAPGVERS PEELEQGQVD IYGPKTPYAT KELTYTEATF DKLVKLSEYN
   841  ILNNKDTLLQ ALRLAVEKKK RLKGQCPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLA2G4E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • skin: 15 nTPM
  • tonsil: 2.2 nTPM
  • esophagus: 2.1 nTPM
  • cervix: 1.9 nTPM
  • vagina: 1.3 nTPM
  • salivary gland: 0.5 nTPM

Single-cell type

  • suprabasal keratinocytes: 176 nCPM
  • esophageal suprabasal cells: 64 nCPM
  • esophageal apical cells: 56 nCPM
  • basal keratinocytes: 42 nCPM
  • late spermatids: 27 nCPM
  • cone photoreceptor cells: 21 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • thalamus: 0.1 nTPM
  • cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
1.14
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLA2G4E as an antibody target. Whether an autoantibody or antibody against PLA2G4E could matter depends on whether native PLA2G4E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLA2G4E is annotated at the cell surface, where native PLA2G4E is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLA2G4E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLA2G4E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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