Seroatlas · Human Serome Atlas

C2CD4C

C2 calcium-dependent domain-containing protein 4C

Also known as: C2C4C_HUMAN, FAM148C, KIAA1957, NLF3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF44
Gene: C2CD4C
Ensembl: ENSG00000183186
Chromosome: 19
Canonical length: 421 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Microtubules,Primary cilium,Primary cilium tip,Basal body

OverviewNCBI Gene

Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q8TF44|C2CD4C
     1  MRKTNMWFLE RLRGSGENGA ARGVGSEAGD KASKGPLYSN VLTPDKIPDF FIPPKLPSGP
    61  AEGEGQAALG PSTSEQNLAS AAPRQTPRSP RLPAKLAAES KSLLKAATRH VIQIESAEDW
   121  LSEEATDADP QAQGAMSLPS VPKAQTSYGF AMLAESPHTR RKESLFHSEH GALAQVGSPG
   181  AGRRRAAAKA NGGDGGPREA GGALMSPGRY FSGGESDTGS SAESSPFGSP LLSRSVSLLK
   241  GFAQDSQAKV SQLRHSVGRH GSLSADDSTP DASPGSRRRL TRRAPPEPGP ESGQARGEHT
   301  VHVGPRGSVR LLAEYEAGQA RLRVHLLAAE GLYDRLCDAR SINCCVGLCL VPGKLQKQRS
   361  TIVKNSRRPV FNEDFFFDGL GPASVRKLAL RIKVVNKGSS LKRDTLLGEK ELPLTSLLPF
   421  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2CD4C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 27 nTPM
amygdala: 22 nTPM
hypothalamus: 18 nTPM
hippocampal formation: 10 nTPM
midbrain: 6 nTPM
basal ganglia: 5.8 nTPM

Single-cell type

other brain neurons: 18 nCPM
oligodendrocyte progenitor cells: 8.6 nCPM
lymphatic endothelial cells: 5.7 nCPM
brain excitatory neurons: 5.2 nCPM
neuroendocrine cells: 4.3 nCPM
rod photoreceptor cells: 4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 33 nTPM
cerebral cortex: 26 nTPM
basal ganglia: 19 nTPM
amygdala: 16 nTPM
pons: 14 nTPM
spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.47
gnomAD missense Z: 1.43
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2CD4C as an antibody target. Whether an autoantibody or antibody against C2CD4C could matter depends on whether native C2CD4C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2CD4C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C2CD4C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...