Seroatlas · Human Serome Atlas

RASA4B

Ras GTPase-activating protein 4B

Also known as: RAS4B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9J798
Gene
RASA4B
Ensembl
ENSG00000170667
Chromosome
7
Canonical length
803 aa
Protein class
Predicted intracellular proteins, RAS pathway related proteins
Subcellular location
Vesicles,Cell Junctions

OverviewNCBI Gene

Predicted to enable GTPase activator activity; phospholipid binding activity; and zinc ion binding activity. Predicted to be involved in cellular response to calcium ion; intracellular signal transduction; and negative regulation of Ras protein signal transduction. Predicted to be located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

803 residues, UniProt reviewed canonical sequence.

>C9J798|RASA4B
     1  MAKRSSLYIR IVEGKNLPAK DITGSSDPYC IVKVDNEPII RTATVWKTLC PFWGEEYQVH
    61  LPPTFHAVAF YVMDEDALSR DDVIGKVCLT RDTIASHPKG FSGWAHLTEV DPDEEVQGEI
   121  HLRLEVWPGA RACRLRCSVL EARDLAPKDR NGTSDPFVRV RYKGRTRETS IVKKSCYPRW
   181  NETFEFELQE GAMEALCVEA WDWDLVSRND FLGKVVIDVQ RLRVVQQEEG WFRLQPDQSK
   241  SRRHDEGNLG SLQLEVRLRD ETVLPSSYYQ PLVHLLCHEV KLGMQGPGQL IPLIEETTST
   301  ECRQDVATNL LKLFLGQGLA KDFLDLLFQL ELSRTSETNT LFRSNSLASK SVESFLKVAG
   361  MQYLHGVLGP IINKVFEEKK YVELDPSKVE VKDVGCSGLH RPQTEAEVLE QSAQTLRAHL
   421  GALLSALSRS VRACPAVVRA TFRQLFRRVR ERFPGAQHEN VPFIAVTSFL CLRFFSPAIM
   481  SPKLFHLRER HADARTSRTL LLLAKAVQNV GNMDTPASRA KEAWMEPLQP TVHQGVAQLK
   541  DFITKLVDIE EKDELDLQRT LSLQAPPVKE GPLFIHRTKG KGPLMSSSFK KLYFSLTTEA
   601  LSFAKTPSSK KSALIKLANI RAAEKVEEKS FGGSHVMQVI YTDDAGRPQT AYLQCKCVNE
   661  LNQWLSALRK VSINNTGLLG SYHPGVFRGD KWSCCHQKEK TGQGCDKTRS RVTLQEWNDP
   721  LDHDLEAQLI YRHLLGVEAM LWERHRELSG GAEAGTVPTS PGKVPEDSLA RLLRVLQDLR
   781  EAHSSSPAGS PPSEPNCLLE LQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASA4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
93 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 93 nTPM
  • endometrium: 17 nTPM
  • adipose tissue: 15 nTPM
  • cervix: 15 nTPM
  • tongue: 14 nTPM
  • colon: 12 nTPM

Single-cell type

  • myonuclei: 161 nCPM
  • neuroendocrine cells: 23 nCPM
  • retinal bipolar cells: 21 nCPM
  • retinal horizontal cells: 20 nCPM
  • vascular endothelial cells: 18 nCPM
  • enterocytes: 18 nCPM

Immune cell

  • myeloid DC: 3.2 nTPM
  • classical monocyte: 2.2 nTPM
  • plasmacytoid DC: 1.9 nTPM
  • intermediate monocyte: 1.6 nTPM
  • total PBMC: 1.2 nTPM
  • MAIT T-cell: 0.4 nTPM

Brain region

  • hypothalamus: 16 nTPM
  • midbrain: 15 nTPM
  • medulla oblongata: 15 nTPM
  • thalamus: 14 nTPM
  • cerebral cortex: 12 nTPM
  • amygdala: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.45
gnomAD pLI
0.02
gnomAD missense Z
1.02
DepMap mean gene effect
-0.07
DepMap dependency class
selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASA4B as an antibody target. Whether an autoantibody or antibody against RASA4B could matter depends on whether native RASA4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASA4B is annotated at the cell surface, where native RASA4B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RASA4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RASA4B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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