Seroatlas · Human Serome Atlas

CPNE5

Copine-5

Also known as: COPN5, CPN5, CPNE5_HUMAN, KIAA1599

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HCH3
Gene
CPNE5
Ensembl
ENSG00000124772
Chromosome
6
Canonical length
593 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. More variants may exist, but their full-length natures could not be determined. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>Q9HCH3|CPNE5
     1  MEQPEDMASL SEFDSLAGSI PATKVEITVS CRNLLDKDMF SKSDPLCVMY TQGMENKQWR
    61  EFGRTEVIDN TLNPDFVRKF IVDYFFEEKQ NLRFDLYDVD SKSPDLSKHD FLGQAFCTLG
   121  EIVGSPGSRL EKPLTIGAFS LNSRTGKPMP AVSNGGVPGK KCGTIILSAE ELSNCRDVAT
   181  MQFCANKLDK KDFFGKSDPF LVFYRSNEDG TFTICHKTEV MKNTLNPVWQ TFSIPVRALC
   241  NGDYDRTIKV EVYDWDRDGS HDFIGEFTTS YRELARGQSQ FNIYEVVNPK KKMKKKKYVN
   301  SGTVTLLSFA VESECTFLDY IKGGTQINFT VAIDFTASNG NPSQSTSLHY MSPYQLNAYA
   361  LALTAVGEII QHYDSDKMFP ALGFGAKLPP DGRVSHEFPL NGNQENPSCC GIDGILEAYH
   421  RSLRTVQLYG PTNFAPVVTH VARNAAAVQD GSQYSVLLII TDGVISDMAQ TKEAIVNAAK
   481  LPMSIIIVGV GQAEFDAMVE LDGDDVRISS RGKLAERDIV QFVPFRDYVD RTGNHVLSMA
   541  RLARDVLAEI PDQLVSYMKA QGIRPRPPPA APTHSPSQSP ARTPPASPLH THI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPNE5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
132 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 132 nTPM
  • heart muscle: 90 nTPM
  • cerebral cortex: 57 nTPM
  • amygdala: 33 nTPM
  • tonsil: 26 nTPM
  • testis: 25 nTPM

Single-cell type

  • sertoli cells: 215 nCPM
  • plasma cells: 159 nCPM
  • cardiomyocytes: 144 nCPM
  • retinal amacrine cells: 140 nCPM
  • platelets: 114 nCPM
  • brain inhibitory neurons: 92 nCPM

Immune cell

  • memory B-cell: 52 nTPM
  • naive B-cell: 27 nTPM
  • total PBMC: 4.5 nTPM
  • neutrophil: 0.5 nTPM
  • MAIT T-cell: 0.2 nTPM
  • memory CD4 T-cell: 0.2 nTPM

Brain region

  • basal ganglia: 154 nTPM
  • cerebral cortex: 144 nTPM
  • white matter: 60 nTPM
  • amygdala: 49 nTPM
  • midbrain: 39 nTPM
  • hypothalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0
gnomAD missense Z
2.72
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPNE5 as an antibody target. Whether an autoantibody or antibody against CPNE5 could matter depends on whether native CPNE5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPNE5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPNE5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPNE5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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