Seroatlas · Human Serome Atlas

PRKCG

Protein kinase C gamma type

Also known as: KPCG_HUMAN, MGC57564, PKCC, PKCG, PKCgamma, SCA14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P05129
Gene: PRKCG
Ensembl: ENSG00000126583
Chromosome: 19
Canonical length: 697 aa
Protein class: Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

697 residues, UniProt reviewed canonical sequence.

>P05129|PRKCG
     1  MAGLGPGVGD SEGGPRPLFC RKGALRQKVV HEVKSHKFTA RFFKQPTFCS HCTDFIWGIG
    61  KQGLQCQVCS FVVHRRCHEF VTFECPGAGK GPQTDDPRNK HKFRLHSYSS PTFCDHCGSL
   121  LYGLVHQGMK CSCCEMNVHR RCVRSVPSLC GVDHTERRGR LQLEIRAPTA DEIHVTVGEA
   181  RNLIPMDPNG LSDPYVKLKL IPDPRNLTKQ KTRTVKATLN PVWNETFVFN LKPGDVERRL
   241  SVEVWDWDRT SRNDFMGAMS FGVSELLKAP VDGWYKLLNQ EEGEYYNVPV ADADNCSLLQ
   301  KFEACNYPLE LYERVRMGPS SSPIPSPSPS PTDPKRCFFG ASPGRLHISD FSFLMVLGKG
   361  SFGKVMLAER RGSDELYAIK ILKKDVIVQD DDVDCTLVEK RVLALGGRGP GGRPHFLTQL
   421  HSTFQTPDRL YFVMEYVTGG DLMYHIQQLG KFKEPHAAFY AAEIAIGLFF LHNQGIIYRD
   481  LKLDNVMLDA EGHIKITDFG MCKENVFPGT TTRTFCGTPD YIAPEIIAYQ PYGKSVDWWS
   541  FGVLLYEMLA GQPPFDGEDE EELFQAIMEQ TVTYPKSLSR EAVAICKGFL TKHPGKRLGS
   601  GPDGEPTIRA HGFFRWIDWE RLERLEIPPP FRPRPCGRSG ENFDKFFTRA APALTPPDRL
   661  VLASIDQADF QGFTYVNPDF VHPDARSPTS PVPVPVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKCG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 50 nTPM
hippocampal formation: 34 nTPM
cerebral cortex: 33 nTPM
cerebellum: 20 nTPM
amygdala: 19 nTPM
hypothalamus: 6 nTPM

Single-cell type

salivary myoepithelial cells: 145 nCPM
endometrial stromal cells: 74 nCPM
breast myoepithelial cells: 72 nCPM
endometrial luminal cells: 59 nCPM
salivary basal cells: 52 nCPM
brain inhibitory neurons: 49 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 247 nTPM
cerebral cortex: 174 nTPM
amygdala: 138 nTPM
basal ganglia: 130 nTPM
white matter: 78 nTPM
thalamus: 66 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRKCG.

Disease | AllUniProt

Conditions PRKCG is implicated in, by any mechanism.

Spinocerebellar ataxia 14 (SCA14) MIM:605361

Disease | GeneticClinVar

51 pathogenic / likely-pathogenic of 383 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spinocerebellar ataxia type 14
Hereditary ataxia
Frontotemporal dementia
Ataxia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 3.06
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKCG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKCG as an antibody target. Whether an autoantibody or antibody against PRKCG could matter depends on whether native PRKCG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKCG is annotated at the cell surface, where native PRKCG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRKCG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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