Seroatlas · Human Serome Atlas

CPNE7

Copine-7

Also known as: CPNE7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBL6
Gene
CPNE7
Ensembl
ENSG00000178773
Chromosome
16
Canonical length
633 aa
Protein class
Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains and one von Willebrand factor A domain. The encoded protein may be involved in membrane trafficking. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

633 residues, UniProt reviewed canonical sequence.

>Q9UBL6|CPNE7
     1  MSAGSERGAA ATPGGLPAPC ASKVELRLSC RHLLDRDPLT KSDPSVALLQ QAQGQWVQVG
    61  RTEVVRSSLH PVFSKVFTVD YYFEEVQRLR FEVYDTHGPS GFSCQEDDFL GGMECTLGQP
   121  AQKWLLQVVM RVSVDVLGPA GHCAKHFLCC TESSHLARTG PSFLLRYDDL CLPWATAGAV
   181  RWWTCRGGHT QGWQIVAQKK VTRPLLLKFG RNAGKSTITV IAEDISGNNG YVELSFRARK
   241  LDDKDLFSKS DPFLELYRVN DDQGLQLVYR TEVVKNNLNP VWEAFKVSLS SLCSCEETRP
   301  LKCLVWDYDS RGKHDFIGEF STTFEEMQKA FEEGQAQWDC VNPKYKQKRR SYKNSGVVVL
   361  ADLKFHRVYS FLDYIMGGCQ IHFTVAIDFT ASNGDPRNSC SLHYINPYQP NEYLKALVSV
   421  GEICQDYDSD KRFSALGFGA RIPPKYEVSH DFAINFNPED DECEGIQGVV EAYQNCLPRV
   481  QLYGPTNVAP IISKVARVAA AEESTGKASQ YYILLILTDG VVTDMADTRE AIVRASRLPM
   541  SIIIVGVGNA DFTDMQVLDG DDGVLRSPRG EPALRDIVQF VPFRELKNAS PAALAKCVLA
   601  EVPKQVVEYY SHRGLPPRSL GVPAGEASPG CTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPNE7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 18 nTPM
  • cerebral cortex: 17 nTPM
  • hypothalamus: 16 nTPM
  • pituitary gland: 13 nTPM
  • amygdala: 10 nTPM
  • hippocampal formation: 8.8 nTPM

Single-cell type

  • epididymal principal cells: 75 nCPM
  • innate lymphoid cells: 48 nCPM
  • corticotrophs: 39 nCPM
  • differentiating spermatogonia: 35 nCPM
  • other brain neurons: 24 nCPM
  • retinal amacrine cells: 23 nCPM

Immune cell

  • MAIT T-cell: 4.9 nTPM
  • memory CD8 T-cell: 1.8 nTPM
  • memory CD4 T-cell: 1.1 nTPM
  • NK-cell: 0.9 nTPM
  • gdT-cell: 0.7 nTPM
  • T-reg: 0.2 nTPM

Brain region

  • thalamus: 62 nTPM
  • cerebral cortex: 39 nTPM
  • midbrain: 36 nTPM
  • amygdala: 31 nTPM
  • basal ganglia: 31 nTPM
  • hypothalamus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.38
gnomAD pLI
0
gnomAD missense Z
-0.98
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPNE7 as an antibody target. Whether an autoantibody or antibody against CPNE7 could matter depends on whether native CPNE7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPNE7 is annotated at the cell surface, where native CPNE7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPNE7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPNE7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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