Seroatlas · Human Serome Atlas

RIMS3

Regulating synaptic membrane exocytosis protein 3

Also known as: NIM3, RIM3, RIMS3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJD0
Gene: RIMS3
Ensembl: ENSG00000117016
Chromosome: 1
Canonical length: 308 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Mitochondria

OverviewNCBI Gene

Predicted to enable transmembrane transporter binding activity. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in several processes, including regulated exocytosis; regulation of synapse organization; and regulation of synaptic vesicle exocytosis. Predicted to be located in presynaptic active zone. Predicted to be active in several cellular components, including postsynaptic cytosol; presynaptic active zone cytoplasmic component; and presynaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>Q9UJD0|RIMS3
     1  MFNGEPGPAS SGASRNVVRS SSISGEICGS QQAGGGAGTT TAKKRRSSLG AKMVAIVGLT
    61  QWSKSTLQLP QPEGATKKLR SNIRRSTETG IAVEMRSRVT RQGSRESTDG STNSNSSDGT
   121  FIFPTTRLGA ESQFSDFLDG LGPAQIVGRQ TLATPPMGDV HIAIMDRSGQ LEVEVIEARG
   181  LTPKPGSKSL PATYIKVYLL ENGACLAKKK TKMTKKTCDP LYQQALLFDE GPQGKVLQVI
   241  VWGDYGRMDH KCFMGMAQIM LDELDLSAAV TGWYKLFPTS SVADSTLGSL TRRLSQSSLE
   301  SATSPSCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIMS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 98 nTPM
cerebellum: 40 nTPM
hypothalamus: 29 nTPM
amygdala: 25 nTPM
basal ganglia: 20 nTPM
hippocampal formation: 12 nTPM

Single-cell type

late spermatids: 60 nCPM
adrenal medulla cells: 43 nCPM
brain inhibitory neurons: 28 nCPM
other brain neurons: 26 nCPM
brain excitatory neurons: 25 nCPM
pdcs: 20 nCPM

Immune cell

plasmacytoid DC: 1.5 nTPM
MAIT T-cell: 0.5 nTPM
memory CD4 T-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM

Brain region

thalamus: 304 nTPM
cerebral cortex: 244 nTPM
midbrain: 150 nTPM
amygdala: 148 nTPM
white matter: 140 nTPM
basal ganglia: 136 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.97
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIMS3 as an antibody target. Whether an autoantibody or antibody against RIMS3 could matter depends on whether native RIMS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIMS3 is annotated at the cell surface, where native RIMS3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RIMS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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