UNC13C

Protein identityUniProt · HPA

UniProt accession

Q8NB66

Gene

UNC13C

Ensembl

ENSG00000137766

Chromosome

15

Canonical length

2214 aa

Protein class

Predicted intracellular proteins

Subcellular location

Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable calmodulin binding activity and syntaxin-1 binding activity. Predicted to be involved in glutamatergic synaptic transmission and regulated exocytosis. Predicted to be located in presynaptic active zone. Predicted to be active in several cellular components, including axon terminus; parallel fiber to Purkinje cell synapse; and synaptic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

2214 residues, UniProt reviewed canonical sequence.

>Q8NB66|UNC13C
     1  MVANFFKSLI LPYIHKLCKG MFTKKLGNTN KNKEYRQQKK DQDFPTAGQT KSPKFSYTFK
    61  STVKKIAKCS STHNLSTEED EASKEFSLSP TFSYRVAIAN GLQKNAKVTN SDNEDLLQEL
   121  SSIESSYSES LNELRSSTEN QAQSTHTMPV RRNRKSSSSL APSEGSSDGE RTLHGLKLGA
   181  LRKLRKWKKS QECVSSDSEL STMKKSWGIR SKSLDRTVRN PKTNALEPGF SSSGCISQTH
   241  DVMEMIFKEL QGISQIETEL SELRGHVNAL KHSIDEISSS VEVVQSEIEQ LRTGFVQSRR
   301  ETRDIHDYIK HLGHMGSKAS LRFLNVTEER FEYVESVVYQ ILIDKMGFSD APNAIKIEFA
   361  QRIGHQRDCP NAKPRPILVY FETPQQRDSV LKKSYKLKGT GIGISTDILT HDIRERKEKG
   421  IPSSQTYESM AIKLSTPEPK IKKNNWQSPD DSDEDLESDL NRNSYAVLSK SELLTKGSTS
   481  KPSSKSHSAR SKNKTANSSR ISNKSDYDKI SSQLPESDIL EKQTTTHYAD ATPLWHSQSD
   541  FFTAKLSRSE SDFSKLCQSY SEDFSENQFF TRTNGSSLLS SSDRELWQRK QEGTATLYDS
   601  PKDQHLNGGV QGIQGQTETE NTETVDSGMS NGMVCASGDR SHYSDSQLSL HEDLSPWKEW
   661  NQGADLGLDS STQEGFDYET NSLFDQQLDV YNKDLEYLGK CHSDLQDDSE SYDLTQDDNS
   721  SPCPGLDNEP QGQWVGQYDS YQGANSNELY QNQNQLSMMY RSQSELQSDD SEDAPPKSWH
   781  SRLSIDLSDK TFSFPKFGST LQRAKSALEV VWNKSTQSLS GYEDSGSSLM GRFRTLSQST
   841  ANESSTTLDS DVYTEPYYYK AEDEEDYTEP VADNETDYVE VMEQVLAKLE NRTSITETDE
   901  QMQAYDHLSY ETPYETPQDE GYDGPADDMV SEEGLEPLNE TSAEMEIRED ENQNIPEQPV
   961  EITKPKRIRP SFKEAALRAY KKQMAELEEK ILAGDSSSVD EKARIVSGND LDASKFSALQ
  1021  VCGGAGGGLY GIDSMPDLRR KKTLPIVRDV AMTLAARKSG LSLAMVIRTS LNNEELKMHV
  1081  FKKTLQALIY PMSSTIPHNF EVWTATTPTY CYECEGLLWG IARQGMKCLE CGVKCHEKCQ
  1141  DLLNADCLQR AAEKSSKHGA EDKTQTIITA MKERMKIREK NRPEVFEVIQ EMFQISKEDF
  1201  VQFTKAAKQS VLDGTSKWSA KITITVVSAQ GLQAKDKTGS SDPYVTVQVG KNKRRTKTIF
  1261  GNLNPVWDEK FYFECHNSTD RIKVRVWDED DDIKSRVKQH FKKESDDFLG QTIVEVRTLS
  1321  GEMDVWYNLE KRTDKSAVSG AIRLKINVEI KGEEKVAPYH IQYTCLHENL FHYLTEVKSN
  1381  GGVKIPEVKG DEAWKVFFDD ASQEIVDEFA MRYGIESIYQ AMTHFSCLSS KYMCPGVPAV
  1441  MSTLLANINA FYAHTTVSTN IQVSASDRFA ATNFGREKFI KLLDQLHNSL RIDLSKYREN
  1501  FPASNTERLQ DLKSTVDLLT SITFFRMKVL ELQSPPKASM VVKDCVRACL DSTYKYIFDN
  1561  CHELYSQLTD PSKKQDIPRE DQGPTTKNLD FWPQLITLMV TIIDEDKTAY TPVLNQFPQE
  1621  LNMGKISAEI MWTLFALDMK YALEEHENQR LCKSTDYMNL HFKVKWFYNE YVRELPAFKD
  1681  AVPEYSLWFE PFVMQWLDEN EDVSMEFLHG ALGRDKKDGF QQTSEHALFS CSVVDVFAQL
  1741  NQSFEIIKKL ECPNPEALSH LMRRFAKTIN KVLLQYAAIV SSDFSSHCDK ENVPCILMNN
  1801  IQQLRVQLEK MFESMGGKEL DSEASTILKE LQVKLSGVLD ELSVTYGESF QVIIEECIKQ
  1861  MSFELNQMRA NGNTTSNKNS AAMDAEIVLR SLMDFLDKTL SLSAKICEKT VLKRVLKELW
  1921  KLVLNKIEKQ IVLPPLTDQT GPQMIFIAAK DLGQLSKLKE HMIREDARGL TPRQCAIMEV
  1981  VLATIKQYFH AGGNGLKKNF LEKSPDLQSL RYALSLYTQT TDALIKKFID TQTSQSRSSK
  2041  DAVGQISVHV DITATPGTGD HKVTVKVIAI NDLNWQTTAM FRPFVEVCIL GPNLGDKKRK
  2101  QGTKTKSNTW SPKYNETFQF ILGKENRPGA YELHLSVKDY CFAREDRIIG MTVIQLQNIA
  2161  EKGSYGAWYP LLKNISMDET GLTILRILSQ RTSDDVAKEF VRLKSETRST EESA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNC13C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

40 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.54

gnomAD pLI

0

gnomAD missense Z

-0.14

DepMap mean gene effect

-0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chemical synaptic transmission
• dense core granule priming
• negative regulation of synaptic plasticity
• synaptic transmission, glutamatergic
• synaptic vesicle docking
• synaptic vesicle priming

Molecular functions

• calcium ion binding
• calmodulin binding
• diacylglycerol binding
• phospholipid binding
• syntaxin-1 binding
• zinc ion binding

Cellular components

• calyx of Held
• neuromuscular junction
• parallel fiber to Purkinje cell synapse
• plasma membrane
• presynaptic active zone
• presynaptic membrane
• synaptic vesicle membrane
• terminal bouton

Protein domainsUniProt · Pfam · InterPro

• C2 domain
• Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
• MUN domain
• Munc13 homology 1
• Mammalian uncoordinated homology 13, domain 2
• Protein Unc-13
• C2 domain superfamily
• Protein Unc-13, C2B domain
• C1-like domain superfamily
• Phorbol esters/diacylglycerol binding domain (C1 domain)
• C2 domain
• MUN domain

KeywordsUniProt

• Calcium
• Cell membrane
• Cell projection
• Coiled coil
• Cytoplasm
• Exocytosis
• Membrane
• Metal-binding
• Phosphoprotein
• Repeat
• Synapse
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of UNC13C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SNAP25
• VAMP2