Seroatlas · Human Serome Atlas

SYT15B

Synaptotagmin-15B

Also known as: CHR10SYT, ST15B_HUMAN, SYT15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: X6R8R1
Gene: SYT15B
Ensembl: ENSG00000277758
Chromosome: 10
Canonical length: 474 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in regulation of calcium ion-dependent exocytosis and vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in exocytic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>X6R8R1|SYT15B
     1  MGVVLSPHPA PSRREPLAPL APGTRPGWSP AVSGSSRSAL RPSTAGPGPG PGTGWGGTAA
    61  SGRWVPAPAV HCAAPRAAAG HQQHHGPPLC SPDGAPRRFK RRPGSPAPAA QTGETSLREQ
   121  PHGGPPAVPF VVPPTLQGRD WVPLHSGEWA DAPWDPCPAS ELLPHTSSGG LGDACMVGAI
   181  NPELYKFPED KSETDFPDGC LGRLWFSVEY EQEAERLLVG LIKAQHLQAP SETCSPLVKL
   241  YLLPDERRFL QSKTKRKTSN PQFDEHFIFQ VSSKTITQRV LKFSVYHVDR QRKHQLLGQV
   301  LFPLKNETLV GDCRRVIWRD LEAESLEPPS EFGDLQFCLS YNDYLSRLTV VVLRAKGLRL
   361  QEDRGIVSVF VKVSLMNHNK FVKCKKTSAV LGSINPVYNE TFSFKADATE LDTASLSLTV
   421  VQNMEGDKSQ QLGRVVVGPY MYTRGRELEH WDEMLSKPKE LVKRWHALCR TTEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT15B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 7.7 nTPM

Expression across tissuesHPA

Tissue

lung: 7.7 nTPM
skin: 5.3 nTPM
cerebral cortex: 4.5 nTPM
pancreas: 3.5 nTPM
lymph node: 3.4 nTPM
placenta: 3.4 nTPM

Single-cell type

alveolar cells type 1: 9.8 nCPM
vascular endothelial cells: 9.1 nCPM
alveolar cells type 2: 3.4 nCPM
lymphatic endothelial cells: 2.9 nCPM
kupffer cells: 2 nCPM
transitional alveolar cells: 2 nCPM

Immune cell

intermediate monocyte: 1.2 nTPM
non-classical monocyte: 1 nTPM
classical monocyte: 0.5 nTPM
gdT-cell: 0.5 nTPM
MAIT T-cell: 0.5 nTPM
memory CD4 T-cell: 0.5 nTPM

Brain region

cerebral cortex: 32 nTPM
hippocampal formation: 29 nTPM
amygdala: 21 nTPM
pons: 20 nTPM
basal ganglia: 20 nTPM
thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT15B as an antibody target. Whether an autoantibody or antibody against SYT15B could matter depends on whether native SYT15B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT15B is annotated at the cell surface, where native SYT15B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYT15B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...