SYDE2

Protein identityUniProt · HPA

UniProt accession

Q5VT97

Gene

SYDE2

Ensembl

ENSG00000097096

Chromosome

1

Canonical length

1194 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoli,Nucleoli rim,Golgi apparatus

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Acts upstream of or within cell migration. Predicted to be located in cytosol. Predicted to be active in synaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1194 residues, UniProt reviewed canonical sequence.

>Q5VT97|SYDE2
     1  MHDLPPDSGA RRGGRGLADH SFPAGARAPG QPPSRGAAYR RACPRDGERG GGGRPRQQVS
    61  PPRSPQREPR GGQLRTPRMR PSCSRSLESL RVGAKPPPFQ RWPSDSWIRC GAHRDWDEPP
   121  PRGGRMDGWS GDRARAAAPT GLQPPGCKDH GCSSGSPFRD PAGSSVIRSG KGDRQEGPSF
   181  LRPPAVTVKK LQKWMYKGRL LSLGMKGRAR GTAPKVTGTQ AASPNVGALK VRENRVLSVP
   241  PDQRITLTDL FENAYGSSMK GRELEELKDN IEFRGHKPLN SITVSKKRNW LYQSTLRPLN
   301  LEEENKKCQD RSHLSISPVS LPKHQLSQSF LKSSKEYCTY VVCNATNSSL SKNCALDFNE
   361  ENDADDEGEI WYNPIPEDDD LGISSALSFG EADSAVLKLP AVNLSMLSGS DLMKAERHTE
   421  DSLCSSEHAG DIQTTRSNGM NPIHPAHSTE FVQQYKQKLG HKTQEGIMVE DSPMLKSPFA
   481  GSGILAATNS TELGIMEPSS PNPSPVKKGS SINWSLPDKI KSPRTVRKLS MKMKKLPEFS
   541  RKLSVKGTLN YINSPDNTPS LSKYNCREVH HTDILPSGNT TTAAKRNVIS RYHLDTSVSS
   601  QQSYQKKNSM SSKYSCKGGY LSDGDSPELT TKASKHGSEN KFGKGKEIIS NSCSKNEIDI
   661  DAFRHYSFSD QPKCSQYISG LMSVHFYGAE DLKPPRIDSK DVFCAIQVDS VNKARTALLT
   721  CRTTFLDMDH TFNIEIENAQ HLKLVVFSWE PTPRKNRVCC HGTVVLPTLF RVTKTHQLAV
   781  KLEPRGLIYV KVTLMEQWEN SLHGLDINQE PIIFGVDIQK VVEKENIGLM VPLLIQKCIM
   841  EIEKRGCQVV GLYRLCGSAA VKKELREAFE RDSKAVGLCE NQYPDINVIT GVLKDYLREL
   901  PSPLITKQLY EAVLDAMAKS PLKMSSNGCE NDPGDSKYTV DLLDCLPEIE KATLKMLLDH
   961  LKLVASYHEV NKMTCQNLAV CFGPVLLSQR QEPSTHNNRV FTDSEELASA LDFKKHIEVL
  1021  HYLLQLWPVQ RLTVKKSTDN LFPEQKSSLN YLRQKKERPH MLNLSGTDSS GVLRPRQNRL
  1081  DSPLSNRYAG DWSSCGENYF LNTKENLNDV DYDDVPSEDR KIGENYSKMD GPEVMIEQPI
  1141  PMSKECTFQT YLTMQTVEST VDRKNNLKDL QESIDTLIGN LERELNKNKL NMSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYDE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

7.1 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1

gnomAD pLI

0

gnomAD missense Z

0.79

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• activation of GTPase activity
• cell migration
• regulation of Ras protein signal transduction
• regulation of small GTPase mediated signal transduction
• signal transduction

Molecular functions

• GTPase activator activity

Cellular components

• cytosol
• synaptic membrane

Protein domainsUniProt · Pfam · InterPro

• C2 domain
• Rho GTPase-activating protein domain
• Rho GTPase activation protein
• C2 domain superfamily
• Rho GTPase-activating regulator
• SYDE1/2, C2 domain
• RhoGAP domain
• C2 domain of synapse defective Rho GAP protein

KeywordsUniProt

• GTPase activation
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of SYDE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• YWHAB
• YWHAE
• YWHAG