Seroatlas · Human Serome Atlas

SYTL3

Synaptotagmin-like protein 3

Also known as: exophilin-6, SLP3, SYTL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4VX76
Gene: SYTL3
Ensembl: ENSG00000164674
Chromosome: 6
Canonical length: 610 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Vesicles

OverviewNCBI Gene

The protein encoded by this gene belongs to a family of peripheral membrane proteins that play a role in vesicular trafficking. This protein binds phospholipids in the presence of calcium ions. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>Q4VX76|SYTL3
     1  MAQEIDLSAL KELEREAILQ VLYRDQAVQN TEEERTRKLK THLQHLRWKG AKNTDWEHKE
    61  KCCARCQQVL GFLLHRGAVC RGCSHRVCAQ CRVFLRGTHA WKCTVCFEDR NVKIKTGEWF
   121  YEERAKKFPT GGKHETVGGQ LLQSYQKLSK ISVVPPTPPP VSESQCSRSP GRLQEFGQFR
   181  GFNKSVENLF LSLATHVKKL SKSQNDMTSE KHLLATGPRQ CVGQTERRSQ SDTAVNVTTR
   241  KVSAPDILKP LNQEDPKCST NPILKQQNLP SSPAPSTIFS GGFRHGSLIS IDSTCTEMGN
   301  FDNANVTGEI EFAIHYCFKT HSLEICIKAC KNLAYGEEKK KKCNPYVKTY LLPDRSSQGK
   361  RKTGVQRNTV DPTFQETLKY QVAPAQLVTR QLQVSVWHLG TLARRVFLGE VIIPLATWDF
   421  EDSTTQSFRW HPLRAKAEKY EDSVPQSNGE LTVRAKLVLP SRPRKLQEAQ EGTDQPSLHG
   481  QLCLVVLGAK NLPVRPDGTL NSFVKGCLTL PDQQKLRLKS PVLRKQACPQ WKHSFVFSGV
   541  TPAQLRQSSL ELTVWDQALF GMNDRLLGGT RLGSKGDTAV GGDACSLSKL QWQKVLSSPN
   601  LWTDMTLVLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYTL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 47 nTPM
thyroid gland: 24 nTPM
spleen: 18 nTPM
thymus: 16 nTPM
lung: 16 nTPM
salivary gland: 14 nTPM

Single-cell type

nk-cells: 1,925 nCPM
mast cells: 1,831 nCPM
t-cells: 1,637 nCPM
innate lymphoid cells: 1,391 nCPM
neutrophils: 1,072 nCPM
thymocytes: 979 nCPM

Immune cell

basophil: 233 nTPM
NK-cell: 43 nTPM
gdT-cell: 37 nTPM
neutrophil: 36 nTPM
memory CD8 T-cell: 25 nTPM
MAIT T-cell: 22 nTPM

Brain region

choroid plexus: 50 nTPM
white matter: 9.5 nTPM
medulla oblongata: 7.8 nTPM
thalamus: 6.1 nTPM
midbrain: 6 nTPM
spinal cord: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: -0.37
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYTL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RAB27A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYTL3 as an antibody target. Whether an autoantibody or antibody against SYTL3 could matter depends on whether native SYTL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYTL3 is annotated at the cell surface, where native SYTL3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYTL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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