Seroatlas · Human Serome Atlas

SYT5

Synaptotagmin-5

Also known as: SYT5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00445
Gene
SYT5
Ensembl
ENSG00000129990
Chromosome
19
Canonical length
386 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]

Canonical amino-acid sequenceUniProt

386 residues, UniProt reviewed canonical sequence.

>O00445|SYT5
     1  MFPEPPTPGP PSPDTPPDSS RISHGPVPPW ALATIVLVSG LLIFSCCFCL YRKSCRRRTG
    61  KKSQAQAQVH LQEVKGLGQS YIDKVQPEVE ELEPAPSGPG QQVADKHELG RLQYSLDYDF
   121  QSGQLLVGIL QAMGLAALDL GGSSDPYVRV YLLPDKRRRY ETKVHRQTLN PHFGETFAFK
   181  VPYVELGGRV LVMAVYDFDR FSRNDAIGEV RVPMSSVDLG RPVQAWRELQ AAPREEQEKL
   241  GDICFSLRYV PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN
   301  TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAAG GAGLRHWADM
   361  LANPRRPIAQ WHSLRPPDRV RLLPAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
106 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 106 nTPM
  • basal ganglia: 95 nTPM
  • hippocampal formation: 72 nTPM
  • amygdala: 62 nTPM
  • hypothalamus: 59 nTPM
  • pituitary gland: 55 nTPM

Single-cell type

  • pancreatic islet cells: 91 nCPM
  • late spermatids: 77 nCPM
  • lactotrophs: 49 nCPM
  • other brain neurons: 47 nCPM
  • gonadotrophs: 39 nCPM
  • neuroendocrine cells: 36 nCPM

Immune cell

  • basophil: 1.3 nTPM
  • neutrophil: 0.8 nTPM
  • myeloid DC: 0.5 nTPM
  • classical monocyte: 0.2 nTPM
  • eosinophil: 0.2 nTPM
  • memory B-cell: 0.2 nTPM

Brain region

  • cerebral cortex: 154 nTPM
  • hypothalamus: 141 nTPM
  • hippocampal formation: 116 nTPM
  • basal ganglia: 112 nTPM
  • white matter: 98 nTPM
  • amygdala: 92 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
1.19
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYT5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT5 as an antibody target. Whether an autoantibody or antibody against SYT5 could matter depends on whether native SYT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYT5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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