Seroatlas · Human Serome Atlas

C2CD4B

C2 calcium-dependent domain-containing protein 4B

Also known as: C2C4B_HUMAN, FAM148B, NLF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NLJ0
Gene: C2CD4B
Ensembl: ENSG00000205502
Chromosome: 15
Canonical length: 364 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in positive regulation of acute inflammatory response; regulation of cell adhesion; and regulation of vascular permeability involved in acute inflammatory response. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>A6NLJ0|C2CD4B
     1  MRLLEKLCSS AAGSSAPKPA FAKVLTPNRI PEFCIPPRLP APCTLESPIR AAAVPRRCAA
    61  ESDLWPRAAD EDAGRTDWDP RSQAALSLPH LPRVRTTYGF CALLESPHTR RKESLLLGGP
   121  PAPRPRAHSC GGGGGPDAPL GTLCGPRGPG PATPAAPGGP RLPQDALAAG PRRCRLLRVP
   181  DGLLSRALRA GRSRRLARVR SVSSGNEDEE RRAGSESPAR APSSSPLSSR APLPERLEAK
   241  GTVALGRAGD ALRLAAEYCP GTRRLRLRLL RAESLFGGAP GPRAVRCRLS LVLRPPGTAR
   301  WQCSAVVGRS RKASFDQDFC FDGLSEDEVR RLAVRVKARD EGRGRDRGRL LGQGELSLGA
   361  LLLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2CD4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

pancreas: 95 nTPM
stomach: 25 nTPM
adipose tissue: 22 nTPM
breast: 19 nTPM
lung: 13 nTPM
heart muscle: 6.1 nTPM

Single-cell type

pancreatic islet cells: 296 nCPM
vascular endothelial cells: 227 nCPM
endometrial glandular cells: 194 nCPM
fallopian tube ciliated cells: 162 nCPM
breast lactating cells: 134 nCPM
neuroendocrine cells: 130 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 3.9 nTPM
spinal cord: 3.3 nTPM
medulla oblongata: 3.1 nTPM
pons: 3.1 nTPM
amygdala: 2.7 nTPM
midbrain: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -0.01
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2CD4B as an antibody target. Whether an autoantibody or antibody against C2CD4B could matter depends on whether native C2CD4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2CD4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C2CD4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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