Seroatlas · Human Serome Atlas

MCTP1

Multiple C2 and transmembrane domain-containing protein 1

Also known as: FLJ22344, MCTP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6DN14
Gene: MCTP1
Ensembl: ENSG00000175471
Chromosome: 5
Canonical length: 999 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Enables calcium ion binding activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; negative regulation of endocytosis; and negative regulation of response to oxidative stress. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

999 residues, UniProt reviewed canonical sequence.

>Q6DN14|MCTP1
     1  MEPRAAAAGE PEPPAASSSF QARLWKNLQL GVGRSKGGGG GRAGGPERRT ADTPSPSPPP
    61  PVGTGNAPAR GSGAGSRWSG FKKRKQVLDR VFSSSQPNLC CSSPEPLEPG GAGRAEQGST
   121  LRRRIREHLL PAVKGPAAAS GAAGGTPPGG RSPDSAPSSS SASSSLSSSP QPPPRGDRAR
   181  DEGARRQGPG AHLCHQKSSS LPGTACLEQL LEPPPPPAEP ARSPAESRAP ETGEEHGSSQ
   241  KIINTAGTSN AEVPLADPGM YQLDITLRRG QSLAARDRGG TSDPYVKFKI GGKEVFRSKI
   301  IHKNLNPVWE EKACILVDHL REPLYIKVFD YDFGLQDDFM GSAFLDLTQL ELNRPTDVTL
   361  TLKDPHYPDH DLGIILLSVI LTPKEGESRD VTMLMRKSWK RSSKELSENE VVGSYFSVKS
   421  LFWRTCGRPA LPVLGFCRAE LQNPYCKNVQ FQTQSLRLSD LHRKSHLWRG IVSITLIEGR
   481  DLKAMDSNGL SDPYVKFRLG HQKYKSKIMP KTLNPQWREQ FDFHLYEERG GVIDITAWDK
   541  DAGKRDDFIG RCQVDLSALS REQTHKLELQ LEEGEGHLVL LVTLTASATV SISDLSVNSL
   601  EDQKEREEIL KRYSPLRIFH NLKDVGFLQV KVIRAEGLMA ADVTGKSDPF CVVELNNDRL
   661  LTHTVYKNLN PEWNKVFTFN IKDIHSVLEV TVYDEDRDRS ADFLGKVAIP LLSIQNGEQK
   721  AYVLKNKQLT GPTKGVIYLE IDVIFNAVKA SLRTLIPKEQ KYIEEENRLS KQLLLRNFIR
   781  MKRCVMVLVN AAYYVNSCFD WDSPPRSLAA FVLFLFVVWN FELYMIPLVL LLLLTWNYFL
   841  IISGKDNRQR DTVVEDMLED EEEEDDKDDK DSEKKGFINK IYAIQEVCVS VQNILDEVAS
   901  FGERIKNTFN WTVPFLSWLA IVALCVFTAI LYCIPLRYIV LVWGINKFTK KLRSPYAIDN
   961  NELLDFLSRV PSDVQVVQYQ ELKPDPSHSP YKRKKNNLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCTP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 43 nTPM
urinary bladder: 20 nTPM
adipose tissue: 19 nTPM
gallbladder: 17 nTPM
cerebral cortex: 16 nTPM
breast: 15 nTPM

Single-cell type

neutrophils: 5,169 nCPM
vascular endothelial cells: 1,397 nCPM
monocytes: 1,181 nCPM
neutrophil progenitors: 1,058 nCPM
brain excitatory neurons: 850 nCPM
macrophages: 700 nCPM

Immune cell

intermediate monocyte: 41 nTPM
non-classical monocyte: 41 nTPM
neutrophil: 41 nTPM
basophil: 37 nTPM
classical monocyte: 29 nTPM
myeloid DC: 22 nTPM

Brain region

basal ganglia: 115 nTPM
cerebellum: 97 nTPM
hippocampal formation: 83 nTPM
cerebral cortex: 79 nTPM
white matter: 64 nTPM
hypothalamus: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0
gnomAD missense Z: 1.23
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCTP1 as an antibody target. Whether an autoantibody or antibody against MCTP1 could matter depends on whether native MCTP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCTP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCTP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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