Seroatlas · Human Serome Atlas

RIMS4

Regulating synaptic membrane exocytosis protein 4

Also known as: C20orf190, dJ781B1.3, RIMS4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H426
Gene: RIMS4
Ensembl: ENSG00000101098
Chromosome: 20
Canonical length: 269 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable transmembrane transporter binding activity. Predicted to be involved in regulation of membrane potential; regulation of synapse organization; and regulation of synaptic vesicle exocytosis. Predicted to be located in synaptic membrane. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

269 residues, UniProt reviewed canonical sequence.

>Q9H426|RIMS4
     1  MERSQSRLSL SASFEALAIY FPCMNSFDDE DAGDSRRLKG AIQRSTETGL AVEMPSRTLR
    61  QASHESIEDS MNSYGSEGNL NYGGVCLASD AQFSDFLGSM GPAQFVGRQT LATTPMGDVE
   121  IGLQERNGQL EVDIIQARGL TAKPGSKTLP AAYIKAYLLE NGICIAKKKT KVARKSLDPL
   181  YNQVLLFPES PQGKVLQVIV WGNYGRMERK QFMGVARVLL EELDLTTLAV GWYKLFPTSS
   241  MVDPATGPLL RQASQLSLES TVGPCGERS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIMS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 40 nTPM
cerebral cortex: 38 nTPM
hippocampal formation: 27 nTPM
amygdala: 24 nTPM
cerebellum: 17 nTPM
hypothalamus: 14 nTPM

Single-cell type

granulosa cells: 76 nCPM
retinal amacrine cells: 44 nCPM
gonadotrophs: 38 nCPM
retinal horizontal cells: 30 nCPM
retinal ganglion cells: 23 nCPM
epididymal efferent duct absorptive cells: 23 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 82 nTPM
hippocampal formation: 54 nTPM
basal ganglia: 50 nTPM
white matter: 48 nTPM
medulla oblongata: 40 nTPM
amygdala: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.23
gnomAD missense Z: 2.89
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIMS4 as an antibody target. Whether an autoantibody or antibody against RIMS4 could matter depends on whether native RIMS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIMS4 is annotated at the cell surface, where native RIMS4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RIMS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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