Seroatlas · Human Serome Atlas

TOLLIP

Toll-interacting protein

Also known as: IL-1RAcPIP, TOLIP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0E2
Gene
TOLLIP
Ensembl
ENSG00000078902
Chromosome
11
Canonical length
274 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

274 residues, UniProt reviewed canonical sequence.

>Q9H0E2|TOLLIP
     1  MATTVSTQRG PVYIGELPQD FLRITPTQQQ RQVQLDAQAA QQLQYGGAVG TVGRLNITVV
    61  QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW NKVIHCTVPP GVDSFYLEIF
   121  DERAFSMDDR IAWTHITIPE SLRQGKVEDK WYSLSGRQGD DKEGMINLVM SYALLPAAMV
   181  MPPQPVVLMP TVYQQGVGYV PITGMPAVCS PGMVPVALPP AAVNAQPRCS EEDLKAIQDM
   241  FPNMDQEVIR SVLEAQRGNK DAAINSLLQM GEEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOLLIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
130 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 130 nTPM
  • liver: 107 nTPM
  • esophagus: 88 nTPM
  • amygdala: 81 nTPM
  • hippocampal formation: 73 nTPM
  • cerebellum: 73 nTPM

Single-cell type

  • late spermatids: 828 nCPM
  • esophageal apical cells: 453 nCPM
  • esophageal suprabasal cells: 299 nCPM
  • late primary spermatocytes: 237 nCPM
  • platelets: 216 nCPM
  • early spermatids: 159 nCPM

Immune cell

  • neutrophil: 180 nTPM
  • eosinophil: 140 nTPM
  • classical monocyte: 127 nTPM
  • intermediate monocyte: 114 nTPM
  • non-classical monocyte: 109 nTPM
  • myeloid DC: 100 nTPM

Brain region

  • cerebral cortex: 191 nTPM
  • hippocampal formation: 162 nTPM
  • basal ganglia: 151 nTPM
  • white matter: 134 nTPM
  • amygdala: 132 nTPM
  • thalamus: 108 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.08
gnomAD missense Z
1.12
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOLLIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOLLIP as an antibody target. Whether an autoantibody or antibody against TOLLIP could matter depends on whether native TOLLIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOLLIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOLLIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TOLLIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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