Seroatlas · Human Serome Atlas

INPP4A

Inositol polyphosphate-4-phosphatase type I A

Also known as: INP4A_HUMAN, INPP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PE3
Gene: INPP4A
Ensembl: ENSG00000040933
Chromosome: 2
Canonical length: 977 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

977 residues, UniProt reviewed canonical sequence.

>Q96PE3|INPP4A
     1  MTAREHSPRH GARARAMQRA STIDVAADML GLSLAGNIQD PDEPILEFSL ACSELHTPSL
    61  DRKPNSFVAV SVTTPPQAFW TKHAQTEIIE GTNNPIFLSS IAFFQDSLIN QMTQVKLSVY
   121  DVKDRSQGTM YLLGSGTFIV KDLLQDRHHR LHLTLRSAES DRVGNITVIG WQMEEKSDQR
   181  PPVTRSVDTV NGRMVLPVDE SLTEALGIRS KYASLRKDTL LKSVFGGAIC RMYRFPTTDG
   241  NHLRILEQMA ESVLSLHVPR QFVKLLLEED AARVCELEEL GELSPCWESL RRQIVTQYQT
   301  IILTYQENLT DLHQYRGPSF KASSLKADKK LEFVPTNLHI QRMRVQDDGG SDQNYDIVTI
   361  GAPAAHCQGF KSGGLRKKLH KFEETKKHFE ECCTSSGCQS IIYIPQDVVR AKEIIAQINT
   421  LKTQVSYYAE RLSRAAKDRS ATGLERTLAI LADKTRQLVT VCDCKLLANS IHGLNAARPD
   481  YIASKASPTS TEEEQVMLRN DQDTLMARWT GRNSRSSLQV DWHEEEWEKV WLNVDKSLEC
   541  IIQRVDKLLQ KERLHGEGCE DVFPCAGSCT SKKGNPDSHA YWIRPEDPFC DVPSSPCPST
   601  MPSTACHPHL TTHCSPPPEE SSPGEWSEAL YPLLTTLTDC VAMMSDKAKK AMVFLLMQDS
   661  APTIATYLSL QYRRDVVFCQ TLTALICGFI IKLRNCLHDD GFLRQLYTIG LLAQFESLLS
   721  TYGEELAMLE DMSLGIMDLR NVTFKVTQAT SSASADMLPV ITGNRDGFNV RVPLPGPLFD
   781  ALPREIQSGM LLRVQPVLFN VGINEQQTLA ERFGDTSLQE VINVESLVRL NSYFEQFKEV
   841  LPEDCLPRSR SQTCLPELLR FLGQNVHARK NKNVDILWQA AEICRRLNGV RFTSCKSAKD
   901  RTAMSVTLEQ CLILQHEHGM APQVFTQALE CMRSEGCRRE NTMKNVGSRK YAFNSLQLKA
   961  FPKHYRPPEG TYGKVET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INPP4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 24 nTPM
cerebral cortex: 20 nTPM
thymus: 18 nTPM
spleen: 16 nTPM
basal ganglia: 15 nTPM
lymph node: 15 nTPM

Single-cell type

pdcs: 572 nCPM
neutrophils: 340 nCPM
renal collecting duct intercalated cells: 332 nCPM
nk-cells: 267 nCPM
innate lymphoid cells: 249 nCPM
neutrophil progenitors: 232 nCPM

Immune cell

non-classical monocyte: 3.6 nTPM
MAIT T-cell: 3.2 nTPM
plasmacytoid DC: 2.9 nTPM
NK-cell: 2.7 nTPM
gdT-cell: 2.6 nTPM
intermediate monocyte: 2.3 nTPM

Brain region

cerebral cortex: 94 nTPM
cerebellum: 90 nTPM
basal ganglia: 87 nTPM
hippocampal formation: 76 nTPM
hypothalamus: 70 nTPM
white matter: 69 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about INPP4A.

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 143 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with growth impairment, quadriparesis, and poor or absent speech
Dyskeratosis congenita, autosomal dominant 1
Intellectual disability
Pectus excavatum
Microcephaly

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 3.35
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INPP4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

INPP5F

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INPP4A as an antibody target. Whether an autoantibody or antibody against INPP4A could matter depends on whether native INPP4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INPP4A is annotated at the cell surface, where native INPP4A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label INPP4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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