Seroatlas · Human Serome Atlas

CPNE1

Copine-1

Also known as: CPN1, CPNE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99829
Gene: CPNE1
Ensembl: ENSG00000214078
Chromosome: 20
Canonical length: 537 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Nuclear membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

537 residues, UniProt reviewed canonical sequence.

>Q99829|CPNE1
     1  MAHCVTLVQL SISCDHLIDK DIGSKSDPLC VLLQDVGGGS WAELGRTERV RNCSSPEFSK
    61  TLQLEYRFET VQKLRFGIYD IDNKTPELRD DDFLGGAECS LGQIVSSQVL TLPLMLKPGK
   121  PAGRGTITVS AQELKDNRVV TMEVEARNLD KKDFLGKSDP FLEFFRQGDG KWHLVYRSEV
   181  IKNNLNPTWK RFSVPVQHFC GGNPSTPIQV QCSDYDSDGS HDLIGTFHTS LAQLQAVPAE
   241  FECIHPEKQQ KKKSYKNSGT IRVKICRVET EYSFLDYVMG GCQINFTVGV DFTGSNGDPS
   301  SPDSLHYLSP TGVNEYLMAL WSVGSVVQDY DSDKLFPAFG FGAQVPPDWQ VSHEFALNFN
   361  PSNPYCAGIQ GIVDAYRQAL PQVRLYGPTN FAPIINHVAR FAAQAAHQGT ASQYFMLLLL
   421  TDGAVTDVEA TREAVVRASN LPMSVIIVGV GGADFEAMEQ LDADGGPLHT RSGQAAARDI
   481  VQFVPYRRFQ NAPREALAQT VLAEVPTQLV SYFRAQGWAP LKPLPPSAKD PAQAPQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPNE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

thymus: 77 nTPM
tonsil: 77 nTPM
spleen: 72 nTPM
blood vessel: 70 nTPM
endometrium: 67 nTPM
bone marrow: 67 nTPM

Single-cell type

decidual stromal cells: 144 nCPM
oocytes: 143 nCPM
cytotrophoblasts: 139 nCPM
migrating cytotrophoblasts: 135 nCPM
neutrophil progenitors: 127 nCPM
syncytiotrophoblasts: 127 nCPM

Immune cell

NK-cell: 207 nTPM
eosinophil: 181 nTPM
MAIT T-cell: 165 nTPM
total PBMC: 165 nTPM
T-reg: 154 nTPM
myeloid DC: 144 nTPM

Brain region

white matter: 34 nTPM
cerebral cortex: 31 nTPM
choroid plexus: 30 nTPM
medulla oblongata: 30 nTPM
hypothalamus: 27 nTPM
pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.09
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CPNE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPNE1 as an antibody target. Whether an autoantibody or antibody against CPNE1 could matter depends on whether native CPNE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPNE1 is annotated at the cell surface, where native CPNE1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPNE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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