Seroatlas · Human Serome Atlas

CPNE8

Copine-8

Also known as: CPNE8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YQ8
Gene: CPNE8
Ensembl: ENSG00000139117
Chromosome: 12
Canonical length: 564 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

564 residues, UniProt reviewed canonical sequence.

>Q86YQ8|CPNE8
     1  MDSRYNSTAG IGDLNQLSAA IPATRVEVSV SCRNLLDRDT FSKSDPICVL YVQGVGNKEW
    61  REFGRTEVID NTLNPDFVRK FILDYFFEER ENLRFDLYDV DSKSPNLSKH DFLGQVFCTL
   121  GEIVGSQGSR LEKPIVGIPG KKCGTIILTA EELNCCRDAV LMQFCANKLD KKDFFGKSDP
   181  FLVFYRSNED GSFTICHKTE VVKNTLNPVW QAFKISVRAL CNGDYDRTIK VEVYDWDRDG
   241  SHDFIGEFTT SYRELSRGQS QFNVYEVVNP KKKGKKKKYT NSGTVTLLSF LVETEVSFLD
   301  YIKGGTQINF TVAIDFTASN GNPAQPTSLH YMNPYQLNAY GMALKAVGEI VQDYDSDKMF
   361  PALGFGAKLP PDGRISHEFA LNGNPQNPYC DGIEGVMEAY YRSLKSVQLY GPTNFAPVIN
   421  HVARYASSVK DGSQYFVLLI VTDGVISDMA QTKESIVNAS KLPMSIIIVG VGPAEFDAMV
   481  ELDGDDVRVS SRGKYAERDI VQFVPFRDYI DRSGNHILSM ARLAKDVLAE IPEQFLSYMR
   541  ARGIKPSPAP PPYTPPTHVL QTQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPNE8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

liver: 15 nTPM
adipose tissue: 12 nTPM
heart muscle: 12 nTPM
placenta: 11 nTPM
kidney: 11 nTPM
spleen: 10 nTPM

Single-cell type

podocytes: 864 nCPM
vascular endothelial cells: 401 nCPM
lymphatic endothelial cells: 304 nCPM
monocyte progenitors: 239 nCPM
bergmann glia: 237 nCPM
monocytes: 231 nCPM

Immune cell

classical monocyte: 12 nTPM
intermediate monocyte: 9.4 nTPM
myeloid DC: 7.7 nTPM
non-classical monocyte: 6.4 nTPM
NK-cell: 4.5 nTPM
basophil: 2.7 nTPM

Brain region

hippocampal formation: 23 nTPM
cerebral cortex: 22 nTPM
choroid plexus: 21 nTPM
hypothalamus: 21 nTPM
spinal cord: 21 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.01
gnomAD missense Z: 1.91
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPNE8 as an antibody target. Whether an autoantibody or antibody against CPNE8 could matter depends on whether native CPNE8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPNE8 is annotated at the cell surface, where native CPNE8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPNE8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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