Seroatlas · Human Serome Atlas

SYDE1

Rho GTPase-activating protein SYDE1

Also known as: 7h3, FLJ13511, SYD1, SYDE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZW31
Gene
SYDE1
Ensembl
ENSG00000105137
Chromosome
19
Canonical length
735 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intrauterine growth restriction (IUGR). [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

735 residues, UniProt reviewed canonical sequence.

>Q6ZW31|SYDE1
     1  MAEPLLRKTF SRLRGREKLP RKKSDAKERG HPAQRPEPSP PEPEPQAPEG SQAGAEGPSS
    61  PEASRSPARG AYLQSLEPSS RRWVLGGAKP AEDTSLGPGV PGTGEPAGEI WYNPIPEEDP
   121  RPPAPEPPGP QPGSAESEGL APQGAAPASP PTKASRTKSP GPARRLSIKM KKLPELRRRL
   181  SLRGPRAGRE RERAAPAGSV ISRYHLDSSV GGPGPAAGPG GTRSPRAGYL SDGDSPERPA
   241  GPPSPTSFRP YEVGPAARAP PAALWGRLSL HLYGLGGLRP APGATPRDLC CLLQVDGEAR
   301  ARTGPLRGGP DFLRLDHTFH LELEAARLLR ALVLAWDPGV RRHRPCAQGT VLLPTVFRGC
   361  QAQQLAVRLE PQGLLYAKLT LSEQQEAPAT AEPRVFGLPL PLLVERERPP GQVPLIIQKC
   421  VGQIERRGLR VVGLYRLCGS AAVKKELRDA FERDSAAVCL SEDLYPDINV ITGILKDYLR
   481  ELPTPLITQP LYKVVLEAMA RDPPNRVPPT TEGTRGLLSC LPDVERATLT LLLDHLRLVS
   541  SFHAYNRMTP QNLAVCFGPV LLPARQAPTR PRARSSGPGL ASAVDFKHHI EVLHYLLQSW
   601  PDPRLPRQSP DVAPYLRPKR QPPLHLPLAD PEVVTRPRGR GGPESPPSNR YAGDWSVCGR
   661  DFLPCGRDFL SGPDYDHVTG SDSEDEDEEV GEPRVTGDFE DDFDAPFNPH LNLKDFDALI
   721  LDLERELSKQ INVCL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYDE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 41 nTPM
  • endometrium: 30 nTPM
  • cervix: 28 nTPM
  • colon: 27 nTPM
  • ovary: 22 nTPM
  • adipose tissue: 22 nTPM

Single-cell type

  • extravillous trophoblasts: 216 nCPM
  • syncytiotrophoblasts: 195 nCPM
  • pericytes: 37 nCPM
  • late spermatids: 37 nCPM
  • peritubular myoid cells: 36 nCPM
  • migrating cytotrophoblasts: 35 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 26 nTPM
  • medulla oblongata: 13 nTPM
  • thalamus: 11 nTPM
  • midbrain: 9.6 nTPM
  • pons: 9.3 nTPM
  • basal ganglia: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.77
gnomAD missense Z
1.7
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYDE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYDE1 as an antibody target. Whether an autoantibody or antibody against SYDE1 could matter depends on whether native SYDE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYDE1 is annotated at the cell surface, where native SYDE1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYDE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYDE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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