Seroatlas · Human Serome Atlas

SYT2

Synaptotagmin-2

Also known as: SYT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N9I0
Gene
SYT2
Ensembl
ENSG00000143858
Chromosome
1
Canonical length
419 aa
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a synaptic vesicle membrane protein. The encoded protein is thought to function as a calcium sensor in vesicular trafficking and exocytosis. Mutations in this gene are associated with myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q8N9I0|SYT2
     1  MRNIFKRNQE PIVAPATTTA TMPIGPVDNS TESGGAGESQ EDMFAKLKEK LFNEINKIPL
    61  PPWALIAIAV VAGLLLLTCC FCICKKCCCK KKKNKKEKGK GMKNAMNMKD MKGGQDDDDA
   121  ETGLTEGEGE GEEEKEPENL GKLQFSLDYD FQANQLTVGV LQAAELPALD MGGTSDPYVK
   181  VFLLPDKKKK YETKVHRKTL NPAFNETFTF KVPYQELGGK TLVMAIYDFD RFSKHDIIGE
   241  VKVPMNTVDL GQPIEEWRDL QGGEKEEPEK LGDICTSLRY VPTAGKLTVC ILEAKNLKKM
   301  DVGGLSDPYV KIHLMQNGKR LKKKKTTVKK KTLNPYFNES FSFEIPFEQI QKVQVVVTVL
   361  DYDKLGKNEA IGKIFVGSNA TGTELRHWSD MLANPRRPIA QWHSLKPEEE VDALLGKNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 39 nTPM
  • basal ganglia: 5.1 nTPM
  • cerebral cortex: 4.8 nTPM
  • retina: 4.8 nTPM
  • midbrain: 3.2 nTPM
  • spinal cord: 1.9 nTPM

Single-cell type

  • cardiomyocytes: 193 nCPM
  • retinal ganglion cells: 100 nCPM
  • adipocytes: 74 nCPM
  • myonuclei: 68 nCPM
  • salivary myoepithelial cells: 60 nCPM
  • oocytes: 55 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 166 nTPM
  • pons: 152 nTPM
  • medulla oblongata: 116 nTPM
  • cerebellum: 105 nTPM
  • thalamus: 56 nTPM
  • white matter: 52 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SYT2.

Disease | AllUniProt

Conditions SYT2 is implicated in, by any mechanism.

  • Myasthenic syndrome, congenital, 7A, presynaptic, and distal motor neuropathy, autosomal dominant (CMS7A) MIM:616040
  • Myasthenic syndrome, congenital, 7B, presynaptic, autosomal recessive (CMS7B) MIM:619461

Disease | GeneticClinVar

18 pathogenic / likely-pathogenic of 340 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Congenital myasthenic syndrome 7
  • Myasthenic syndrome, congenital, 7B, presynaptic, autosomal recessive
  • Muscle weakness
  • Respiratory distress
  • SYT2-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.98
gnomAD missense Z
1.98
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT2 as an antibody target. Whether an autoantibody or antibody against SYT2 could matter depends on whether native SYT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...