Seroatlas · Human Serome Atlas

CPNE6

Copine-6

Also known as: CPNE6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95741
Gene
CPNE6
Ensembl
ENSG00000100884
Chromosome
14
Canonical length
557 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

557 residues, UniProt reviewed canonical sequence.

>O95741|CPNE6
     1  MSDPEMGWVP EPPTMTLGAS RVELRVSCHG LLDRDTLTKP HPCVLLKLYS DEQWVEVERT
    61  EVLRSCSSPV FSRVLALEYF FEEKQPLQFH VFDAEDGATS PRNDTFLGST ECTLGQIVSQ
   121  TKVTKPLLLK NGKTAGKSTI TIVAEEVSGT NDYVQLTFRA YKLDNKDLFS KSDPFMEIYK
   181  TNEDQSDQLV WRTEVVKNNL NPSWEPFRLS LHSLCSCDVH RPLKFLVYDY DSSGKHDFIG
   241  EFTSTFQEMQ EGTANPGQEM QWDCINPKYR DKKKNYKSSG TVVLAQCTVE KVHTFLDYIM
   301  GGCQISFTVA IDFTASNGDP RSSQSLHCLS PRQPNHYLQA LRAVGGICQD YDSDKRFPAF
   361  GFGARIPPNF EVSHDFAINF DPENPECEEI SGVIASYRRC LPQIQLYGPT NVAPIINRVA
   421  EPAQREQSTG QATKYSVLLV LTDGVVSDMA ETRTAIVRAS RLPMSIIIVG VGNADFSDMR
   481  LLDGDDGPLR CPRGVPAARD IVQFVPFRDF KDAAPSALAK CVLAEVPRQV VEYYASQGIS
   541  PGAPRPCTLA TTPSPSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPNE6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 46 nTPM
  • retina: 22 nTPM
  • seminal vesicle: 21 nTPM
  • cerebellum: 12 nTPM
  • hippocampal formation: 6.9 nTPM
  • amygdala: 6.8 nTPM

Single-cell type

  • epididymal efferent duct absorptive cells: 38 nCPM
  • astrocytes: 29 nCPM
  • late spermatids: 26 nCPM
  • proximal tubule cells: 26 nCPM
  • brain excitatory neurons: 19 nCPM
  • brain inhibitory neurons: 19 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 202 nTPM
  • amygdala: 145 nTPM
  • cerebral cortex: 142 nTPM
  • basal ganglia: 122 nTPM
  • pons: 101 nTPM
  • thalamus: 97 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.15
gnomAD missense Z
2.88
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPNE6 as an antibody target. Whether an autoantibody or antibody against CPNE6 could matter depends on whether native CPNE6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPNE6 is annotated at the cell surface, where native CPNE6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CPNE6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPNE6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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