Seroatlas · Human Serome Atlas

CC2D2B

Protein CC2D2B

Also known as: bA248J23.4, bA690P14.3, C10orf130, C10orf131, C2D2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6DHV5
Gene
CC2D2B
Ensembl
ENSG00000188649
Chromosome
10
Canonical length
1437 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Nucleoli rim

OverviewNCBI Gene

Predicted to be involved in non-motile cilium assembly and protein localization to ciliary transition zone. Predicted to be active in ciliary transition zone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1437 residues, UniProt reviewed canonical sequence.

>Q6DHV5|CC2D2B
     1  MKKSQREDIF KKMSEEMDNI TAEEIIDKHL QKDLDAEENQ NVAKTLRGKV REKLKISKIN
    61  KGEKSSTEQL IDSEIHQRSK LSPQTEVSLD ESLSFFILSG EEGSALGKSS EQRPVNRSYP
   121  KCFSLGVNLQ NVAESEEEEF MKEFILTDIL KVKAADYEDD QEQIKKQKAN IFVPSSSPVV
   181  NQRKLPKDMM PRILEDEGFY IQRKPEIYKK TCNKMENRLL KLEEGKCWFG ESGEIMSLPT
   241  PIKQSWNFRL NVRKEPLNPL LKTIYRKAVK YDLGSSFMNK MEGSREIYQL DLNIVGLQFS
   301  HHHLFNQEQV LCARLLQLYE CFQDRQQQNV SQLLYEKLKA LTDATKLSNE NSEINQLTRK
   361  SLQDYYWQIS NTKQMYDLER GKDLSLLHSI LRTWKQIKSL RHGQGFTSTP IKLQVQRIKM
   421  NKCDEQEQIS EMSETEKKNE GKELKNGKKL ESLSYLASDE TEIERIKPIT LRPQLSFTAE
   481  LTSLSKCSLH EQKRRAKIQK LKYFIKIFYN NKQVSCTSVS PLQFDFKVMF QQIFNIQLMY
   541  WPEVICLEVY EKSKRTSLLA KLYIPLPNYT ELKGKTALQY VEFSSDKLVM PADGEVGSNV
   601  PFLLEGNGTE ELCLLTSGKL SYSLSWSLDE NGLPLIPMPQ SLRSSYCSML RNVDARSVPG
   661  IPWLMNEQKL FEWANEVRID PNNPEYSDLM ESVTYMRLKG QDIPKYFRLE QLQDEFNFVS
   721  EEEMAKSKRF QLLQLRNAGQ LDNFLLQQMP LHDTEIPDLV FQEYESQKEK EVSVSDVNSI
   781  TAQRINSANF LKKVRRLIMK RIVKISKCNL SDIVNDYEEI VSTSQLTDAV CKFVEPRRKL
   841  KPQRKERKKV TAQAISDGDI KILVRIVRAY NIPTRKTTIN GSLDMPTCLK SSISCLRHRE
   901  TIKSVASDET LHEDTVHPFV EVSFQHTVYK TNTASGSHPC WNEEIKVDFV SPGHDYSFSS
   961  LSKIKDNIYI NIFDEMMTEK HEDHCLKSCS GHSYIRKNWL GCIVFPFSAL LQQSEISGTF
  1021  QVTIPPVLLG YTWSNTYVFP KEDSNEQNLK ECTFLNIFAT IEPQISYVTC NPTLDKFLDQ
  1081  TEVLQRAQIF KKNCKAMFPN RRIVTTVFND EGIQFLVTRY IKALNPPQQL LDIFLHNSNA
  1141  TFDLIARFVS LIPFVPNTPD ENDGSDIWMT SEHCISLAIG NKEEHAILLC NFFLYFGKKA
  1201  LVLLGTSVLE GHVAYVVTQE TNEYLLWNPS TGQCYKQFDP FCPLKSVDCL FDDRNVWFNI
  1261  QQNNTPMAVF FDYSKESFWK QLLPKNVQGT KIQSIQPEEI IYFETDKSMV EDLRNRIERT
  1321  LKSKVMEWRP KHPTHWNRQC TFILRQILPK LEFGIGSFVS SEGDNEFERI LQFYWVTGFP
  1381  IQMPYIDVQS IIDAVYQTGI HSAEFPQTEF ALAVYIHPYP NNILSVWVYL ASLVQHQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CC2D2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
8.1 nTPM

Expression across tissuesHPA

Tissue

  • testis: 8.1 nTPM
  • thyroid gland: 2.8 nTPM
  • retina: 2.5 nTPM
  • bone marrow: 2.3 nTPM
  • cerebral cortex: 2.3 nTPM
  • skin: 2.3 nTPM

Single-cell type

  • cardiomyocytes: 262 nCPM
  • adipocytes: 128 nCPM
  • epicardial cells: 127 nCPM
  • neutrophils: 93 nCPM
  • late primary spermatocytes: 92 nCPM
  • astrocytes: 84 nCPM

Immune cell

  • memory B-cell: 1.2 nTPM
  • naive B-cell: 1.2 nTPM
  • MAIT T-cell: 0.9 nTPM
  • gdT-cell: 0.5 nTPM
  • memory CD4 T-cell: 0.4 nTPM
  • naive CD4 T-cell: 0.4 nTPM

Brain region

  • white matter: 32 nTPM
  • choroid plexus: 29 nTPM
  • hypothalamus: 29 nTPM
  • pons: 27 nTPM
  • basal ganglia: 27 nTPM
  • thalamus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.97
gnomAD pLI
0
gnomAD missense Z
1.29
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CC2D2B as an antibody target. Whether an autoantibody or antibody against CC2D2B could matter depends on whether native CC2D2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CC2D2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CC2D2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CC2D2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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