Seroatlas · Human Serome Atlas

PRKCD

Protein kinase C delta type

Also known as: KPCD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q05655
Gene: PRKCD
Ensembl: ENSG00000163932
Chromosome: 3
Canonical length: 676 aa
Protein class: Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

676 residues, UniProt reviewed canonical sequence.

>Q05655|PRKCD
     1  MAPFLRIAFN SYELGSLQAE DEANQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKSTFD
    61  AHIYEGRVIQ IVLMRAAEEP VSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY
   121  FLEDVDCKQS MRSEDEAKFP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKDFVW
   181  GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFNIDMP HRFKVHNYMS
   241  PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCREKVANLC GINQKLLAEA LNQVTQRASR
   301  RSDSASSEPV GIYQGFEKKT GVAGEDMQDN SGTYGKIWEG SSKCNINNFI FHKVLGKGSF
   361  GKVLLGELKG RGEYFAIKAL KKDVVLIDDD VECTMVEKRV LTLAAENPFL THLICTFQTK
   421  DHLFFVMEFL NGGDLMYHIQ DKGRFELYRA TFYAAEIMCG LQFLHSKGII YRDLKLDNVL
   481  LDRDGHIKIA DFGMCKENIF GESRASTFCG TPDYIAPEIL QGLKYTFSVD WWSFGVLLYE
   541  MLIGQSPFHG DDEDELFESI RVDTPHYPRW ITKESKDILE KLFEREPTKR LGVTGNIKIH
   601  PFFKTINWTL LEKRRLEPPF RPKVKSPRDY SNFDQEFLNE KARLSYSDKN LIDSMDQSAF
   661  AGFSFVNPKF EHLLED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKCD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 71 nTPM
tonsil: 53 nTPM
stomach: 52 nTPM
adrenal gland: 50 nTPM
spleen: 46 nTPM
small intestine: 46 nTPM

Single-cell type

neutrophils: 357 nCPM
platelets: 143 nCPM
late spermatids: 140 nCPM
esophageal apical cells: 117 nCPM
neutrophil progenitors: 106 nCPM
enterocytes: 106 nCPM

Immune cell

classical monocyte: 72 nTPM
intermediate monocyte: 70 nTPM
myeloid DC: 55 nTPM
basophil: 50 nTPM
neutrophil: 48 nTPM
eosinophil: 48 nTPM

Brain region

cerebral cortex: 28 nTPM
hypothalamus: 27 nTPM
white matter: 26 nTPM
basal ganglia: 25 nTPM
amygdala: 24 nTPM
medulla oblongata: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRKCD.

Disease | AllUniProt

Conditions PRKCD is implicated in, by any mechanism.

Autoimmune lymphoproliferative syndrome 3 (ALPS3) MIM:615559

Disease | GeneticClinVar

19 pathogenic / likely-pathogenic of 649 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD
Lymphoma

Disease | ImmuneIEDB

Conditions an epitope on PRKCD was assayed in.

rheumatoid arthritis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 3.11
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRKCD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKCD as an antibody target. Whether an autoantibody or antibody against PRKCD could matter depends on whether native PRKCD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKCD is annotated at the cell surface, where native PRKCD is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

Defects in this gene are a cause of autoimmune lymphoproliferative syndrome.

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