Seroatlas · Human Serome Atlas

CCDC33

Coiled-coil domain-containing protein 33

Also known as: CCD33_HUMAN, CT61, FLJ32855

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5R6
Gene: CCDC33
Ensembl: ENSG00000140481
Chromosome: 15
Canonical length: 958 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

958 residues, UniProt reviewed canonical sequence.

>Q8N5R6|CCDC33
     1  MAFRGPEPWV SASLLRQRLK AEEKTLDLEF EVLSVGFNEA GRYALRLSAE NPLQVGSGAG
    61  VQLQVNDGDP FPACSAITDV IEQQEPGQSL TLTRSKFIFT LPKGFCKNDG QHDAQLHVEA
   121  LRLDEPLGRA AQRVGEAIFP IYPRPDQPRM NPKAQDHEDL YRYCGNLALL RASTDPTARH
   181  CGSLAYSVAF HVHRGPQPPV SDSPPRAGQP ELMSPEEPLI ASQSTEPEIG HLSPSKKETI
   241  MVTLHGATNL PACKDGSEPW PYVVVKSTSE EKNNQSSKAV TSVTSEPTRA PIWGDTVNVE
   301  IQAEDAGQED VILKVVDNRK KQELLSYKIP IKYLRVFHPY HFELVKPTES GKADEATAKT
   361  QLYATVVRKS SFIPRYIGCN HMALEIFLRG VNEPLANNPN PIVVIARVVP NYKEFKVSQA
   421  NRDLASVGLP ITPLSFPIPS MMNFDVPRVS QNGCPQLSKP GGPPEQPLWN QSFLFQGRDG
   481  ATSFSEDTAL VLEYYSSTSM KGSQPWTLNQ PLGISVLPLK SRLYQKMLTG KGLDGLHVER
   541  LPIMDTSLKT INDEAPTVAL SFQLLSSERP ENFLTPNNSK ALPTLDPKIL DKKLRTIQES
   601  WSKDTVSSTM DLSTSTPREA EEEPLVPEMS HDTEMNNYRR AMQKMAEDIL SLRRQASILE
   661  GENRILRSRL AQQEEEEGQG KASEAQNTVS MKQKLLLSEL DMKKLRDRVQ HLQNELIRKN
   721  DREKELLLLY QAQQPQAALL KQYQGKLQKM KALEETVRHQ EKVIEKMERV LEDRLQDRSK
   781  PPPLNRQQGK PYTGFPMLSA SGLPLGSMGE NLPVELYSVL LAENAKLRTE LDKNRHQQAP
   841  IILQQQALPD LLSGTSDKFN LLAKLEHAQS RILSLESQLE DSARRWGREK QDLATRLQEQ
   901  EKGFRHPSNS IIIEQPSALT HSMDLKQPSE LEPLLPSSDS KLNKPLSPQK ETANSQQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

testis: 19 nTPM
fallopian tube: 18 nTPM
hippocampal formation: 2.9 nTPM
hypothalamus: 2.8 nTPM
lung: 2.7 nTPM
basal ganglia: 2.5 nTPM

Single-cell type

late spermatids: 56 nCPM
retinal pigment epithelial cells: 51 nCPM
fallopian tube ciliated cells: 50 nCPM
ependymal cells: 50 nCPM
respiratory ciliated cells: 42 nCPM
early spermatids: 39 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 7.1 nTPM
spinal cord: 5 nTPM
medulla oblongata: 4.6 nTPM
pons: 2.2 nTPM
hypothalamus: 1.4 nTPM
white matter: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: -0.01
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

peroxisome

Protein domainsUniProt · Pfam · InterPro

C2 domain
C2 domain superfamily
C2 domain
Coiled-coil domain-containing protein 33

KeywordsUniProt

Coiled coil

InteractionsUniProt · HPA

Protein binding partners of CCDC33 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC33 as an antibody target. Whether an autoantibody or antibody against CCDC33 could matter depends on whether native CCDC33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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