DAB2IP
Disabled homolog 2-interacting protein
Also known as: AF9Q34, AIP1, DAB2P_HUMAN, DIP1/2, KIAA1743
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5VWQ8
- Gene
- DAB2IP
- Ensembl
- ENSG00000136848
- Chromosome
- 9
- Canonical length
- 1189 aa
- Protein class
- Disease related genes, Predicted intracellular proteins
OverviewNCBI Gene
DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
Canonical amino-acid sequenceUniProt
1189 residues, UniProt reviewed canonical sequence.
>Q5VWQ8|DAB2IP
1 MSAGGSARKS TGRSSYYYRL LRRPRLQRQR SRSRSRTRPA RESPQERPGS RRSLPGSLSE
61 KSPSMEPSAA TPFRVTGFLS RRLKGSIKRT KSQPKLDRNH SFRHILPGFR SAAAAAADNE
121 RSHLMPRLKE SRSHESLLSP SSAVEALDLS MEEEVVIKPV HSSILGQDYC FEVTTSSGSK
181 CFSCRSAAER DKWMENLRRA VHPNKDNSRR VEHILKLWVI EAKDLPAKKK YLCELCLDDV
241 LYARTTGKLK TDNVFWGEHF EFHNLPPLRT VTVHLYRETD KKKKKERNSY LGLVSLPAAS
301 VAGRQFVEKW YPVVTPNPKG GKGPGPMIRI KARYQTITIL PMEMYKEFAE HITNHYLGLC
361 AALEPILSAK TKEEMASALV HILQSTGKVK DFLTDLMMSE VDRCGDNEHL IFRENTLATK
421 AIEEYLKLVG QKYLQDALGE FIKALYESDE NCEVDPSKCS AADLPEHQGN LKMCCELAFC
481 KIINSYCVFP RELKEVFASW RQECSSRGRP DISERLISAS LFLRFLCPAI MSPSLFNLLQ
541 EYPDDRTART LTLIAKVTQN LANFAKFGSK EEYMSFMNQF LEHEWTNMQR FLLEISNPET
601 LSNTAGFEGY IDLGRELSSL HSLLWEAVSQ LEQSIVSKLG PLPRILRDVH TALSTPGSGQ
661 LPGTNDLAST PGSGSSSISA GLQKMVIEND LSGLIDFTRL PSPTPENKDL FFVTRSSGVQ
721 PSPARSSSYS EANEPDLQMA NGGKSLSMVD LQDARTLDGE AGSPAGPDVL PTDGQAAAAQ
781 LVAGWPARAT PVNLAGLATV RRAGQTPTTP GTSEGAPGRP QLLAPLSFQN PVYQMAAGLP
841 LSPRGLGDSG SEGHSSLSSH SNSEELAAAA KLGSFSTAAE ELARRPGELA RRQMSLTEKG
901 GQPTVPRQNS AGPQRRIDQP PPPPPPPPPA PRGRTPPNLL STLQYPRPSS GTLASASPDW
961 VGPSTRLRQQ SSSSKGDSPE LKPRAVHKQG PSPVSPNALD RTAAWLLTMN AQLLEDEGLG
1021 PDPPHRDRLR SKDELSQAEK DLAVLQDKLR ISTKKLEEYE TLFKCQEETT QKLVLEYQAR
1081 LEEGEERLRR QQEDKDIQMK GIISRLMSVE EELKKDHAEM QAAVDSKQKI IDAQEKRIAS
1141 LDAANARLMS ALTQLKERYS MQARNGISPT NPTKLQITEN GEFRNSSNCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DAB2IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 145 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 145 nTPM
- endometrium: 44 nTPM
- basal ganglia: 41 nTPM
- blood vessel: 40 nTPM
- skeletal muscle: 40 nTPM
- colon: 39 nTPM
Single-cell type
- myonuclei: 334 nCPM
- müller glia: 254 nCPM
- syncytiotrophoblasts: 175 nCPM
- renal collecting duct intercalated cells: 134 nCPM
- vascular endothelial cells: 106 nCPM
- alveolar cells type 1: 99 nCPM
Immune cell
- MAIT T-cell: 0.4 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebellum: 208 nTPM
- basal ganglia: 99 nTPM
- cerebral cortex: 85 nTPM
- hypothalamus: 83 nTPM
- medulla oblongata: 80 nTPM
- hippocampal formation: 69 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.2
- gnomAD pLI
- 1
- gnomAD missense Z
- 2.36
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- angiogenesis
- cell motility involved in cerebral cortex radial glia guided migration
- cellular response to epidermal growth factor stimulus
- cellular response to interleukin-1
- cellular response to lipopolysaccharide
- cellular response to tumor necrosis factor
- cellular response to unfolded protein
- cellular response to vascular endothelial growth factor stimulus
- endothelial cell apoptotic process
- extrinsic apoptotic signaling pathway via death domain receptors
- inflammatory response
- innate immune response
- intracellular signal transduction
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- layer formation in cerebral cortex
- lipid droplet formation
- negative regulation of angiogenesis
- negative regulation of canonical NF-kappaB signal transduction
- negative regulation of canonical Wnt signaling pathway
- negative regulation of cell population proliferation
- negative regulation of DNA-templated transcription
- negative regulation of endothelial cell migration
- negative regulation of epidermal growth factor receptor signaling pathway
- negative regulation of epithelial cell migration
- negative regulation of epithelial cell proliferation
- negative regulation of epithelial to mesenchymal transition
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of fibroblast proliferation
- negative regulation of G0 to G1 transition
- negative regulation of GTPase activity
- negative regulation of MAPK cascade
- negative regulation of non-canonical NF-kappaB signal transduction
- negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- negative regulation of protein catabolic process
- negative regulation of Ras protein signal transduction
- negative regulation of toll-like receptor 4 signaling pathway
- negative regulation of transcription by RNA polymerase II
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- negative regulation of vascular endothelial growth factor signaling pathway
- neuron projection morphogenesis
- positive regulation of apoptotic process
- positive regulation of apoptotic signaling pathway
- positive regulation of canonical NF-kappaB signal transduction
- positive regulation of dendrite development
- positive regulation of IRE1-mediated unfolded protein response
- positive regulation of JNK cascade
- positive regulation of MAPK cascade
- positive regulation of neuron migration
- positive regulation of neuron projection development
- positive regulation of proteasomal protein catabolic process
- positive regulation of protein catabolic process
- positive regulation of protein-containing complex assembly
- positive regulation of synapse maturation
- positive regulation of transcription by RNA polymerase II
- protein catabolic process
- regulation of canonical NF-kappaB signal transduction
- regulation of cell cycle
- regulation of GTPase activity
- regulation of intracellular signal transduction
- regulation of p38MAPK cascade
- regulation of protein-containing complex assembly
- tube formation
- tumor necrosis factor-mediated signaling pathway
- vascular endothelial growth factor receptor-2 signaling pathway
Molecular functions
- 14-3-3 protein binding
- cadherin binding
- death receptor binding
- GTPase activator activity
- identical protein binding
- kinase binding
- mitogen-activated protein kinase kinase binding
- mitogen-activated protein kinase kinase kinase binding
- phosphatidylinositol 3-kinase binding
- phosphatidylinositol 3-kinase regulatory subunit binding
- phosphatidylinositol-3-phosphate binding
- phosphatidylinositol-4-phosphate binding
- protein homodimerization activity
- protein kinase binding
- protein phosphatase 2A binding
- protein serine/threonine kinase activator activity
- protein-containing complex binding
- SH3 domain binding
- signaling adaptor activity
- vascular endothelial growth factor receptor 2 binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- C2 domain
- Pleckstrin homology domain
- Ras GTPase-activating domain
- Rho GTPase activation protein
- PH-like domain superfamily
- Disabled homolog 2-interacting protein, C-terminal domain
- Ras GTPase-activating protein, conserved site
- C2 domain superfamily
- Ras GTPase-activating protein
- Ras/Rap GTPase-activating protein SynGAP-like, PH domain
- C2 domain
- GTPase-activator protein for Ras-like GTPase
- Disabled homolog 2-interacting protein, C-terminal domain
- PH domain-like
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of DAB2IP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DAB2IP as an antibody target. Whether an autoantibody or antibody against DAB2IP could matter depends on whether native DAB2IP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DAB2IP is annotated at the cell surface, where native DAB2IP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label DAB2IP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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