Seroatlas · Human Serome Atlas

RASAL3

RAS protein activator like-3

Also known as: FLJ21438, RASL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YV0
Gene: RASAL3
Ensembl: ENSG00000105122
Chromosome: 19
Canonical length: 1011 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

1011 residues, UniProt reviewed canonical sequence.

>Q86YV0|RASAL3
     1  MDPPSPSRTS QTQPTATSPL TSYRWHTGGG GEKAAGGFRW GRFAGWGRAL SHQEPMVSTQ
    61  PAPRSIFRRV LSAPPKESRT SRLRLSKALW GRHKNPPPEP DPEPEQEAPE LEPEPELEPP
   121  TPQIPEAPTP NVPVWDIGGF TLLDGKLVLL GGEEEGPRRP RVGSASSEGS IHVAMGNFRD
   181  PDRMPGKTEP ETAGPNQVHN VRGLLKRLKE KKKARLEPRD GPPSALGSRE SLATLSELDL
   241  GAERDVRIWP LHPSLLGEPH CFQVTWTGGS RCFSCRSAAE RDRWIEDLRR QFQPTQDNVE
   301  REETWLSVWV HEAKGLPRAA AGAPGVRAEL WLDGALLART APRAGPGQLF WAERFHFEAL
   361  PPARRLSLRL RGLGPGSAVL GRVALALEEL DAPRAPAAGL ERWFPLLGAP AGAALRARIR
   421  ARRLRVLPSE RYKELAEFLT FHYARLCGAL EPALPAQAKE ELAAAMVRVL RATGRAQALV
   481  TDLGTAELAR CGGREALLFR ENTLATKAID EYMKLVAQDY LQETLGQVVR RLCASTEDCE
   541  VDPSKCPASE LPEHQARLRN SCEEVFETII HSYDWFPAEL GIVFSSWREA CKERGSEVLG
   601  PRLVCASLFL RLLCPAILAP SLFGLAPDHP APGPARTLTL IAKVIQNLAN RAPFGEKEAY
   661  MGFMNSFLEE HGPAMQCFLD QVAMVDVDAA PSGYQGSGDL ALQLAVLHAQ LCTIFAELDQ
   721  TTRDTLEPLP TILRAIEEGQ PVLVSVPMRL PLPPAQVHSS LSAGEKPGFL APRDLPKHTP
   781  LISKSQSLRS VRRSESWARP RPDEERPLRR PRPVQRTQSV PVRRPARRRQ SAGPWPRPKG
   841  SLSMGPAPRA RPWTRDSASL PRKPSVPWQR QMDQPQDRNQ ALGTHRPVNK LAELQCEVAA
   901  LREEQKVLSR LVESLSTQIR ALTEQQEQLR GQLQDLDSRL RAGSSEFDSE HNLTSNEGHS
   961  LKNLEHRLNE MERTQAQLRD AVQSLQLSPR TRGSWSQPQP LKAPCLNGDT T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASAL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

spleen: 39 nTPM
lymph node: 31 nTPM
bone marrow: 22 nTPM
thymus: 22 nTPM
small intestine: 19 nTPM
tonsil: 18 nTPM

Single-cell type

nk-cells: 98 nCPM
t-cells: 93 nCPM
neutrophil progenitors: 65 nCPM
microglia: 61 nCPM
innate lymphoid cells: 55 nCPM
b-cells: 46 nCPM

Immune cell

memory CD8 T-cell: 20 nTPM
gdT-cell: 18 nTPM
eosinophil: 13 nTPM
non-classical monocyte: 13 nTPM
NK-cell: 12 nTPM
memory CD4 T-cell: 12 nTPM

Brain region

white matter: 7.6 nTPM
thalamus: 5.6 nTPM
medulla oblongata: 5.5 nTPM
spinal cord: 5.2 nTPM
pons: 4.8 nTPM
cerebral cortex: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0
gnomAD missense Z: 1.6
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASAL3 as an antibody target. Whether an autoantibody or antibody against RASAL3 could matter depends on whether native RASAL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASAL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASAL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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