Seroatlas · Human Serome Atlas

SYTL4

Synaptotagmin-like protein 4

Also known as: SYTL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96C24
Gene: SYTL4
Ensembl: ENSG00000102362
Chromosome: X
Canonical length: 671 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

671 residues, UniProt reviewed canonical sequence.

>Q96C24|SYTL4
     1  MSELLDLSFL SEEEKDLILS VLQRDEEVRK ADEKRIRRLK NELLEIKRKG AKRGSQHYSD
    61  RTCARCQESL GRLSPKTNTC RGCNHLVCRD CRIQESNGTW RCKVCAKEIE LKKATGDWFY
   121  DQKVNRFAYR TGSEIIRMSL RHKPAVSKRE TVGQSLLHQT QMGDIWPGRK IIQERQKEPS
   181  VLFEVPKLKS GKSALEAESE SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE
   241  TQPGGQNVVF VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL
   301  NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSMSTIGS MMSIYSEAGD FGNIFVTGRI
   361  AFSLKYEQQT QSLVVHVKEC HQLAYADEAK KRSNPYVKTY LLPDKSRQGK RKTSIKRDTI
   421  NPLYDETLRY EIPESLLAQR TLQFSVWHHG RFGRNTFLGE AEIQMDSWKL DKKLDHCLPL
   481  HGKISAESPT GLPSHKGELV VSLKYIPASK TPVGGDRKKS KGGEGGELQV WIKEAKNLTA
   541  AKAGGTSDSF VKGYLLPMRN KASKRKTPVM KKTLNPHYNH TFVYNGVRLE DLQHMCLELT
   601  VWDREPLASN DFLGGVRLGV GTGISNGEVV DWMDSTGEEV SLWQKMRQYP GSWAEGTLQL
   661  RSSMAKQKLG L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYTL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

ovary: 49 nTPM
endometrium: 40 nTPM
smooth muscle: 30 nTPM
cervix: 20 nTPM
pituitary gland: 17 nTPM
fallopian tube: 17 nTPM

Single-cell type

somatotrophs: 585 nCPM
gonadotrophs: 439 nCPM
thyrotrophs: 432 nCPM
corticotrophs: 351 nCPM
platelets: 234 nCPM
ovarian stromal cells: 210 nCPM

Immune cell

neutrophil: 1.6 nTPM
total PBMC: 0.8 nTPM
basophil: 0.5 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

hypothalamus: 41 nTPM
choroid plexus: 32 nTPM
basal ganglia: 31 nTPM
midbrain: 23 nTPM
medulla oblongata: 21 nTPM
thalamus: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SYTL4.

Disease | ImmuneIEDB

Conditions an epitope on SYTL4 was assayed in.

skin melanoma T cell
melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0.01
gnomAD missense Z: 0.81
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

C2 domain
Synaptotagmin
Rab-binding domain
Zinc finger, FYVE/PHD-type
Zinc finger, RING/FYVE/PHD-type
C2 domain superfamily
Synaptotagmin-like protein 4/5, C2A domain
FYVE-type zinc finger
Synaptotagmin-like 1-5, C2B domain
C2 domain
FYVE-type zinc finger
Synaptotagmin-like protein 4 , FYVE-related domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYTL4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYTL4 as an antibody target. Whether an autoantibody or antibody against SYTL4 could matter depends on whether native SYTL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYTL4 is annotated at the cell surface, where native SYTL4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYTL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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