Seroatlas · Human Serome Atlas

C2CD4A

C2 calcium-dependent domain-containing protein 4A

Also known as: C2C4A_HUMAN, FAM148A, NLF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCU7
Gene: C2CD4A
Ensembl: ENSG00000198535
Chromosome: 15
Canonical length: 369 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Involved in positive regulation of acute inflammatory response; regulation of cell adhesion; and regulation of vascular permeability involved in acute inflammatory response. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>Q8NCU7|C2CD4A
     1  MWCLERLRLG PECLRRSGDW LLPGRARGAK SRTTAACANV LTPDRIPEFC IPPRLMPRLA
    61  LAALRNSWVE EAGMDEGAGR TDWDPRSQAA LSLPHLPRVR TAYGFCALLE SPHTRRKESL
   121  LLGGPPAPRP RAHTYGGGGG PDALLGTLRV PRAPGPATPA APGCPRPPQD ALARRPRGCR
   181  LLRVPDGLLS RALRAGRSRR LTRVRSVSSG NEDKERRAGS QSPARAPSTS PPSSRVPFPE
   241  RLEAEGTVAL GRAGDALRLA AEYCPGTGRL RLRLLRAESP AGGAPGPRAV SCRLSLVLRP
   301  PGTALRQCST VVGRSRKASF DQDFCFDGLS EDEVRRLAVR VKARDEGRGR ERGRLLGQGE
   361  LSLGALLLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C2CD4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 13 nTPM
pancreas: 3.8 nTPM
urinary bladder: 3.4 nTPM
liver: 2.2 nTPM
kidney: 2.1 nTPM
stomach: 2 nTPM

Single-cell type

pancreatic islet cells: 243 nCPM
endometrial glandular cells: 194 nCPM
ocular epithelial cells: 36 nCPM
medullary thymic epithelial cells: 34 nCPM
endometrial luminal cells: 24 nCPM
endometrial secretory cells: 23 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0.2 nTPM
T-reg: 0.2 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

hypothalamus: 6.5 nTPM
cerebral cortex: 5.6 nTPM
medulla oblongata: 3.4 nTPM
midbrain: 3 nTPM
pons: 2.7 nTPM
choroid plexus: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about C2CD4A.

Disease | ImmuneIEDB

Conditions an epitope on C2CD4A was assayed in.

colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0.02
gnomAD missense Z: -0.25
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C2CD4A as an antibody target. Whether an autoantibody or antibody against C2CD4A could matter depends on whether native C2CD4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C2CD4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C2CD4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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