SYTL5

Protein identityUniProt · HPA

UniProt accession

Q8TDW5

Gene

SYTL5

Ensembl

ENSG00000147041

Chromosome

X

Canonical length

730 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

730 residues, UniProt reviewed canonical sequence.

>Q8TDW5|SYTL5
     1  MSKNSEFINL SFLLDHEKEM ILGVLKRDEY LKKVEDKRIR KLKNELLEAK RRSGKTQQEA
    61  SRVCVHCHRN LGLIFDRGDP CQACSLRVCR ECRVAGPNGS WKCTVCDKIA QLRIITGEWF
   121  FEEKAKRFKQ VNVLGTDVVR QSILRRSPGA EEVQSQEQTR QDAEKSDTSP VAGKKASHDG
   181  PKRKGFLLSK FRSATRGEII TPKTDTGRSY SLDLDGQHFR SLKSPPGSDR GSTGSSDLND
   241  QEPGPRTPKS SRSNGVTPGT QSSPAPSTRT VTSVISREYG FENSMDLAAI EGTSQELTKS
   301  HRRNTSGTPS IAVSGTSLSS DQSRSELDLS ESFTEDSEDT VSIRSKSVPG ALDKDSLEET
   361  EESIDALVSS QLSTNTHRLA SGLSTTSLNS MMSVYSETGD YGNVKVSGEI LLHISYCYKT
   421  GGLYIFVKNC RNLAIGDEKK QRTDAYVKSY LLPDKSRNNK RKTKIRTGTN PEFNETLKYT
   481  ISHTQLETRT LQLSVWHYDR FGRNSFLGEV EIPFDSWNFE NPTDEWFVLQ PKVEFAPDIG
   541  LQYKGELTVV LRYIPPEENL MLPPEQLQGN KTFKKGKKKE SPVISGGILE VFIKEAKNLT
   601  AVKSGGTSDS FVKGYLLPDD SKATKHKTLV IKKSVNPQWN HTFMFSGIHP QDIKNVCLEL
   661  TIWDKEAFSS NIFLGGVRLN SGSGVSHGKN VDWMDSQGEE QRLWQKMANN PGTPFEGVLM
   721  LRSSMGKCRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYTL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

13 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.65

gnomAD pLI

0

gnomAD missense Z

-0.39

DepMap mean gene effect

0.17

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• exocytosis
• intracellular protein transport

Molecular functions

• neurexin family protein binding
• phospholipid binding
• small GTPase binding
• zinc ion binding

Cellular components

• exocytic vesicle
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• C2 domain
• Rab-binding domain
• Zinc finger, FYVE/PHD-type
• Zinc finger, RING/FYVE/PHD-type
• C2 domain superfamily
• Synaptotagmin-like protein 4/5, C2A domain
• FYVE-type zinc finger
• Synaptotagmin-like 1-5, C2B domain
• C2 domain
• FYVE-type zinc finger
• Synaptotagmin-l, FYVE-related domain

KeywordsUniProt

• Membrane
• Metal-binding
• Phosphoprotein
• Repeat
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of SYTL5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RAB27B