Seroatlas · Human Serome Atlas

SYT7

Synaptotagmin-7

Also known as: IPCA-7, MGC150517, PCANAP7, SYT-VII, SYT7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43581
Gene
SYT7
Ensembl
ENSG00000011347
Chromosome
11
Canonical length
403 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>O43581|SYT7
     1  MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK NSLETVGTPD
    61  SGRGRSEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTEP RSSVSDLVNS LTSEMLMLSP
   121  GSEEDEAHEG CSRENLGRIQ FSVGYNFQES TLTVKIMKAQ ELPAKDFSGT SDPFVKIYLL
   181  PDKKHKLETK VKRKNLNPHW NETFLFEGFP YEKVVQRILY LQVLDYDRFS RNDPIGEVSI
   241  PLNKVDLTQM QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG
   301  TSDPYVKVWL MYKDKRVEKK KTVTMKRNLN PIFNESFAFD IPTEKLRETT IIITVMDKDK
   361  LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ LKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • liver: 79 nTPM
  • cerebral cortex: 60 nTPM
  • salivary gland: 54 nTPM
  • cerebellum: 50 nTPM
  • prostate: 48 nTPM
  • pituitary gland: 46 nTPM

Single-cell type

  • prostatic glandular cells: 200 nCPM
  • somatotrophs: 168 nCPM
  • gonadotrophs: 165 nCPM
  • pancreatic islet cells: 141 nCPM
  • salivary duct cells: 122 nCPM
  • conjunctival goblet cells: 113 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 285 nTPM
  • white matter: 199 nTPM
  • basal ganglia: 145 nTPM
  • thalamus: 142 nTPM
  • hippocampal formation: 138 nTPM
  • amygdala: 134 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
2.21
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYT7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYT7 as an antibody target. Whether an autoantibody or antibody against SYT7 could matter depends on whether native SYT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYT7 is annotated at the cell surface, where native SYT7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYT7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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