Seroatlas · Human Serome Atlas

SYTL1

Synaptotagmin-like protein 1

Also known as: exophilin-7, FLJ14996, JFC1, SLP1, SYTL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYJ3
Gene: SYTL1
Ensembl: ENSG00000142765
Chromosome: 1
Canonical length: 562 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable neurexin family protein binding activity. Involved in exocytosis. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

562 residues, UniProt reviewed canonical sequence.

>Q8IYJ3|SYTL1
     1  MPQRGHPSQE GLWALPSLPM AHGPKPETEG LLDLSFLTEE EQEAIAGVLQ RDARLRQLEE
    61  GRVSKLRASV ADPGQLKILT GDWFQEARSQ RHHNAHFGSD LVRASMRRKK STRGDQAPGH
   121  DREAEAAVKE KEEGPEPRLT IDEAPQERLR ETEGPDFPSP SVPLKASDPE EASQAQEDPG
   181  QGDQQVCAEE ADPELEPASG GEQEPRPQQA QTKAASQILE NGEEAPGPDP SLDRMLSSSS
   241  SVSSLNSSTL SGSQMSLSGD AEAVQVRGSV HFALHYEPGA AELRVHVIQC QGLAAARRRR
   301  SDPYVKSYLL PDKQSKRKTA VKKRNLNPVF NETLRYSVPQ AELQGRVLSL SVWHRESLGR
   361  NIFLGEVEVP LDTWDWGSEP TWLPLQPRVP PSPDDLPSRG LLALSLKYVP AGSEGAGLPP
   421  SGELHFWVKE ARDLLPLRAG SLDTYVQCFV LPDDSQASRQ RTRVVRRSLS PVFNHTMVYD
   481  GFGPADLRQA CAELSLWDHG ALANRQLGGT RLSLGTGSSY GLQVPWMDST PEEKQLWQAL
   541  LEQPCEWVDG LLPLRTNLAP RT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYTL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 101 nTPM

Expression across tissuesHPA

Tissue

pancreas: 101 nTPM
esophagus: 99 nTPM
skin: 83 nTPM
prostate: 62 nTPM
vagina: 48 nTPM
salivary gland: 46 nTPM

Single-cell type

esophageal apical cells: 375 nCPM
esophageal suprabasal cells: 327 nCPM
esophageal basal cells: 223 nCPM
prostatic hillock cells: 144 nCPM
suprabasal keratinocytes: 135 nCPM
respiratory basal cells: 127 nCPM

Immune cell

eosinophil: 177 nTPM
non-classical monocyte: 101 nTPM
gdT-cell: 65 nTPM
T-reg: 64 nTPM
MAIT T-cell: 59 nTPM
memory CD8 T-cell: 53 nTPM

Brain region

cerebellum: 18 nTPM
choroid plexus: 13 nTPM
amygdala: 8.4 nTPM
hypothalamus: 2.7 nTPM
cerebral cortex: 2.6 nTPM
hippocampal formation: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYTL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYTL1 as an antibody target. Whether an autoantibody or antibody against SYTL1 could matter depends on whether native SYTL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYTL1 is annotated at the cell surface, where native SYTL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SYTL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...