RASAL2

Protein identityUniProt · HPA

UniProt accession

Q9UJF2

Gene

RASAL2

Ensembl

ENSG00000075391

Chromosome

1

Canonical length

1139 aa

Protein class

Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins

Subcellular location

Plasma membrane,Focal adhesion sites

OverviewNCBI Gene

This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1139 residues, UniProt reviewed canonical sequence.

>Q9UJF2|RASAL2
     1  MQTPEVPAER SPRRRSISGT STSEKPNSMD TANTSPFKVP GFFSKRLKGS IKRTKSQSKL
    61  DRNTSFRLPS LRSTDDRSRG LPKLKESRSH ESLLSPCSTV ECLDLGRGEP VSVKPLHSSI
   121  LGQDFCFEVT YLSGSKCFSC NSASERDKWM ENLRRTVQPN KDNCRRAENV LRLWIIEAKD
   181  LAPKKKYFCE LCLDDTLFAR TTSKTKADNI FWGEHFEFFS LPPLHSITVH IYKDVEKKKK
   241  KDKNNYVGLV NIPTASVTGR QFVEKWYPVS TPTPNKGKTG GPSIRIKSRF QTITILPMEQ
   301  YKEFAEFVTS NYTMLCSVLE PVISVRNKEE LACALVHILQ STGRAKDFLT DLVMSEVDRC
   361  GEHDVLIFRE NTIATKSIEE YLKLVGQQYL HDALGEFIKA LYESDENCEV DPSKCSSSEL
   421  IDHQSNLKMC CELAFCKIIN SYCVFPRELK EVFASWKQQC LNRGKQDISE RLISASLFLR
   481  FLCPAIMSPS LFNLMQEYPD DRTSRTLTLI AKVIQNLANF AKFGNKEEYM AFMNDFLEHE
   541  WGGMKRFLLE ISNPDTISNT PGFDGYIDLG RELSVLHSLL WEVVSQLDKG ENSFLQATVA
   601  KLGPLPRVLA DITKSLTNPT PIQQQLRRFT EHNSSPNVSG SLSSGLQKIF EDPTDSDLHK
   661  LKSPSQDNTD SYFRGKTLLL VQQASSQSMT YSEKDERESS LPNGRSVSLM DLQDTHAAQV
   721  EHASVMLDVP IRLTGSQLSI TQVASIKQLR ETQSTPQSAP QVRRPLHPAL NQPGGLQPLS
   781  FQNPVYHLNN PIPAMPKASI DSSLENLSTA SSRSQSNSED FKLSGPSNSS MEDFTKRSTQ
   841  SEDFSRRHTV PDRHIPLALP RQNSTGQAQI RKVDQGGLGA RAKAPPSLPH SASLRSTGSM
   901  SVVSAALVAE PVQNGSRSRQ QSSSSRESPV PKVRAIQRQQ TQQVQSPVDS ATMSPVERTA
   961  AWVLNNGQYE EDVEETEQNL DEAKHAEKYE QEITKLKERL RVSSRRLEEY ERRLLVQEQQ
  1021  MQKLLLEYKA RLEDSEERLR RQQEEKDSQM KSIISRLMAV EEELKKDHAE MQAVIDAKQK
  1081  IIDAQEKRIV SLDSANTRLM SALTQVKERY SMQVRNGISP TNPTKLSITE NGEFKNSSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASAL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

25 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RASAL2.

Disease | ImmuneIEDB

Conditions an epitope on RASAL2 was assayed in.

• pancreatic ductal adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.34

gnomAD pLI

0.8

gnomAD missense Z

1.4

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adipose tissue development
• gene expression
• multicellular organism growth
• regulation of intracellular signal transduction
• response to dietary excess
• response to glucose
• signal transduction
• regulation of protein activation cascade

Molecular functions

• GTPase activator activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• C2 domain
• Pleckstrin homology domain
• Ras GTPase-activating domain
• Rho GTPase activation protein
• Disabled homolog 2-interacting protein, C-terminal domain
• Ras GTPase-activating protein, conserved site
• C2 domain superfamily
• Ras GTPase-activating protein
• Ras/Rap GTPase-activating protein SynGAP-like, PH domain
• C2 domain
• GTPase-activator protein for Ras-like GTPase
• Disabled homolog 2-interacting protein, C-terminal domain
• PH domain-like

KeywordsUniProt

• GTPase activation
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of RASAL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PEAK1
• CSNK1A1
• MCC
• YWHAB
• YWHAE
• YWHAG
• YWHAH
• YWHAQ