Seroatlas · Human Serome Atlas

RASAL1

RasGAP-activating-like protein 1

Also known as: RASAL, RASL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95294
Gene: RASAL1
Ensembl: ENSG00000111344
Chromosome: 12
Canonical length: 804 aa
Protein class: Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Plasma membrane,Cell Junctions,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

804 residues, UniProt reviewed canonical sequence.

>O95294|RASAL1
     1  MAKSSSLNVR VVEGRALPAK DVSGSSDPYC LVKVDDEVVA RTATVWRSLG PFWGEEYTVH
    61  LPLDFHQLAF YVLDEDTVGH DDIIGKISLS REAITADPRG IDSWINLSRV DPDAEVQGEI
   121  CLSVQMLEDG QGRCLRCHVL QARDLAPRDI SGTSDPFARV FWGSQSLETS TIKKTRFPHW
   181  DEVLELREMP GAPSPLRVEL WDWDMVGKND FLGMVEFSPK TLQQKPPKGW FRLLPFPRAE
   241  EDSGGNLGAL RVKVRLIEDR VLPSQCYQPL MELLMESVQG PAEEDTASPL ALLEELTLGD
   301  CRQDLATKLV KLFLGRGLAG RFLDYLTRRE VARTMDPNTL FRSNSLASKS MEQFMKLVGM
   361  PYLHEVLKPV ISRVFEEKKY MELDPCKMDL GRTRRISFKG ALSEEQMRET SLGLLTGYLG
   421  PIVDAIVGSV GRCPPAMRLA FKQLHRRVEE RFPQAEHQDV KYLAISGFLF LRFFAPAILT
   481  PKLFDLRDQH ADPQTSRSLL LLAKAVQSIG NLGQQLGQGK ELWMAPLHPF LLQCVSRVRD
   541  FLDRLVDVDG DEAGVPARAL FPPSAIVREG YLLKRKEEPA GLATRFAFKK RYVWLSGETL
   601  SFSKSPEWQM CHSIPVSHIR AVERVDEGAF QLPHVMQVVT QDGTGALHTT YLQCKNVNEL
   661  NQWLSALRKA SAPNPNKLAA CHPGAFRSAR WTCCLQAERS AAGCSRTHSA VTLGDWSDPL
   721  DPDAEAQTVY RQLLLGRDQL RLKLLEDSNM DTTLEADTGA CPEVLARQRA ATARLLEVLA
   781  DLDRAHEEFQ QQERGKAALG PLGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 56 nTPM
salivary gland: 26 nTPM
esophagus: 23 nTPM
kidney: 15 nTPM
adrenal gland: 15 nTPM
hippocampal formation: 14 nTPM

Single-cell type

esophageal apical cells: 207 nCPM
renal collecting duct principal cells: 176 nCPM
salivary acinar cells: 61 nCPM
renal connecting tubule cells: 59 nCPM
foveolar cells: 56 nCPM
corticotrophs: 50 nCPM

Immune cell

basophil: 0.2 nTPM
MAIT T-cell: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

hippocampal formation: 53 nTPM
cerebral cortex: 49 nTPM
basal ganglia: 31 nTPM
white matter: 29 nTPM
amygdala: 23 nTPM
hypothalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASAL1 as an antibody target. Whether an autoantibody or antibody against RASAL1 could matter depends on whether native RASAL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASAL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASAL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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