Seroatlas · Human Serome Atlas

RGS3

Regulator of G-protein signaling 3

Also known as: C2PA, FLJ20370, PDZ-RGS3, RGS3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49796
Gene: RGS3
Ensembl: ENSG00000138835
Chromosome: 9
Canonical length: 1198 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

1198 residues, UniProt reviewed canonical sequence.

>P49796|RGS3
     1  MPVIPALWEV EMGRSQGQEI ETILANRSHS DSTPLPNFLS GSHRPECCTC RLLTASGAQD
    61  SLPFGRRLYS GPWRSCEEVC HVSVLSVLST SCGLSLSLPI FPGWMEWLSP DIALPRRDEW
   121  TQTSPARKRI THAKVQGAGQ LRLSIDAQDR VLLLHIIEGK GLISKQPGTC DPYVKISLIP
   181  EDSRLRHQKT QTVPDCRDPA FHEHFFFPVQ EEDDQKRLLV TVWNRASQSR QSGLIGCMSF
   241  GVKSLLTPDK EISGWYYLLG EHLGRTKHLK VARRRLRPLR DPLLRMPGGG DTENGKKLKI
   301  TIPRGKDGFG FTICCDSPVR VQAVDSGGPA ERAGLQQLDT VLQLNERPVE HWKCVELAHE
   361  IRSCPSEIIL LVWRMVPQVK PGPDGGVLRR ASCKSTHDLQ SPPNKREKNC THGVQARPEQ
   421  RHSCHLVCDS SDGLLLGGWE RYTEVAKRGG QHTLPALSRA TAPTDPNYII LAPLNPGSQL
   481  LRPVYQEDTI PEESGSPSKG KSYTGLGKKS RLMKTVQTMK GHGNYQNCPV VRPHATHSSY
   541  GTYVTLAPKV LVFPVFVQPL DLCNPARTLL LSEELLLYEG RNKAAEVTLF AYSDLLLFTK
   601  EDEPGRCDVL RNPLYLQSVK LQEGSSEDLK FCVLYLAEKA ECLFTLEAHS QEQKKRVCWC
   661  LSENIAKQQQ LAASPPDSKM FETEADEKRE MALEEGKGPG AEDSPPSKEP SPGQELPPGQ
   721  DLPPNKDSPS GQEPAPSQEP LSSKDSATSE GSPPGPDAPP SKDVPPCQEP PPAQDLSPCQ
   781  DLPAGQEPLP HQDPLLTKDL PAIQESPTRD LPPCQDLPPS QVSLPAKALT EDTMSSGDLL
   841  AATGDPPAAP RPAFVIPEVR LDSTYSQKAG AEQGCSGDEE DAEEAEEVEE GEEGEEDEDE
   901  DTSDDNYGER SEAKRSSMIE TGQGAEGGLS LRVQNSLRRR THSEGSLLQE PRGPCFASDT
   961  TLHCSDGEGA ASTWGMPSPS TLKKELGRNG GSMHHLSLFF TGHRKMSGAD TVGDDDEASR
  1021  KRKSKNLAKD MKNKLGIFRR RNESPGAPPA GKADKMMKSF KPTSEEALKW GESLEKLLVH
  1081  KYGLAVFQAF LRTEFSEENL EFWLACEDFK KVKSQSKMAS KAKKIFAEYI AIQACKEVNL
  1141  DSYTREHTKD NLQSVTRGCF DLAQKRIFGL MEKDSYPRFL RSDLYLDLIN QKKMSPPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 142 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 142 nTPM
blood vessel: 99 nTPM
heart muscle: 89 nTPM
kidney: 67 nTPM
lung: 59 nTPM
adipose tissue: 55 nTPM

Single-cell type

distal convoluted tubule cells: 116 nCPM
vascular endothelial cells: 107 nCPM
cholangiocytes: 102 nCPM
megakaryocytes: 99 nCPM
ependymal cells: 88 nCPM
retinal horizontal cells: 84 nCPM

Immune cell

NK-cell: 43 nTPM
gdT-cell: 25 nTPM
memory CD8 T-cell: 20 nTPM
neutrophil: 19 nTPM
MAIT T-cell: 17 nTPM
total PBMC: 16 nTPM

Brain region

thalamus: 100 nTPM
choroid plexus: 82 nTPM
midbrain: 72 nTPM
basal ganglia: 56 nTPM
cerebellum: 49 nTPM
white matter: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 1.03
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

C2 domain
PDZ domain
PH-like domain superfamily
RGS domain
RGS, subdomain 1/3
C2 domain superfamily
PDZ superfamily
RGS domain superfamily
RGS, subdomain 2
C2 domain
PDZ domain
Regulator of G protein signaling domain
Regulator of G-protein signalling 3, RGS domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GNAI1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS3 as an antibody target. Whether an autoantibody or antibody against RGS3 could matter depends on whether native RGS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS3 is annotated at the cell surface, where native RGS3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RGS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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