Seroatlas · Human Serome Atlas

WWC3

Protein WWC3

Also known as: BM042, KIAA1280, WWC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULE0
Gene: WWC3
Ensembl: ENSG00000047644
Chromosome: X
Canonical length: 1216 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

1216 residues, UniProt reviewed canonical sequence.

>Q9ULE0|WWC3
     1  MPWLSGGRRR RRGQPREAPR EPPPSAQPQR EPPPAPPAAV PTPPAPSAPP PRARESAELP
    61  LPAGWEEARD YDGRVFYIDH NTRQTSWIDP RDRITKPLTF ADCVGDELPL GWETVYDKQI
   121  GVYYMDHINK LTQIEDPREQ WRREQERMLK EYLIVAQEAL NAKKEIYQIK QQRFELAQEE
   181  YQQLHKMCED DSRSYASSFS GYSTNTKYDP HQIKAEIASR RDRLSRLKRE LTQMKQELQY
   241  KEKGVETLQE IDRKMSSTHT SYKLDEAQAI MSELRTIKKA ICTGEKERRD LMHSLAKLTD
   301  SFKNSCSVTD SLVDFPHHVG VPGDAGVPQQ FCDAGSQTDI IGEFVFDDKT RLVDRVRLNW
   361  QYEEARKRVA NIQQQLARLD NESWPSTAEA DRDRLQLIKE KEALLQELQL IIAQRRSAGD
   421  VARLEEERER LEEELRRARA TSAQGATERI LLQEKRNCLL MQLEEATRLT SYLQSQLKSL
   481  CASTLTVSSG SSRGSLASSR GSLASSRGSL SSVSFTDIYG LPQYEKPDAE GSQLLRFDLI
   541  PFDSLGRDAP FSEPPGPSGF HKQRRSLDTP QSLASLSSRS SLSSLSPPSS PLDTPFLPAS
   601  RDSPLAQLAD SCEGPGLGAL DRLRAHASAM GDEDLPGMAA LQPHGVPGDG EGPHERGPPP
   661  ASAPVGGTVT LREDSAKRLE RRARRISACL SDYSLASDSG VFEPLTKRNE DAEEPAYGDT
   721  ASNGDPQIHV GLLRDSGSEC LLVHVLQLKN PAGLAVKEDC KVHIRVYLPP LDSGTPNTYC
   781  SKALEFQVPL VFNEVFRIPV HSSALTLKSL QLYVCSVTPQ LQEELLGIAQ INLADYDSLS
   841  EMQLRWHSVQ VFTSSEPSRT REAGCAGESS ARDPAHTISI SGKTDAVTVL LARTTAQLQA
   901  VERELAEERA KLEYTEEEVL EMERKEEQAE AISERSWQAD SVDSGCSNCT QTSPPYPEPC
   961  CMGIDSILGH PFAAQAGPYS PEKFQPSPLK VDKETNTEDL FLEEAASLVK ERPSRRARGS
  1021  PFVRSGTIVR SQTFSPGARS QYVCRLYRSD SDSSTLPRKS PFVRNTLERR TLRYKQSCRS
  1081  SLAELMARTS LDLELDLQAS RTRQRQLNEE LCALRELRQR LEDAQLRGQT DLPPWVLRDE
  1141  RLRGLLREAE RQTRQTKLDY RHEQAAEKML KKASKEIYQL RGQSHKEPIQ VQTFREKIAF
  1201  FTRPRINIPP LPADDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WWC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

seminal vesicle: 25 nTPM
blood vessel: 22 nTPM
lung: 20 nTPM
epididymis: 18 nTPM
heart muscle: 17 nTPM
ovary: 17 nTPM

Single-cell type

neutrophils: 225 nCPM
alveolar cells type 2: 216 nCPM
platelets: 169 nCPM
adrenal cortex cells: 160 nCPM
alveolar cells type 1: 109 nCPM
epididymal basal cells: 108 nCPM

Immune cell

neutrophil: 11 nTPM
gdT-cell: 5.8 nTPM
naive B-cell: 5 nTPM
MAIT T-cell: 4.9 nTPM
memory CD8 T-cell: 4.3 nTPM
basophil: 4 nTPM

Brain region

basal ganglia: 32 nTPM
white matter: 31 nTPM
midbrain: 29 nTPM
thalamus: 29 nTPM
medulla oblongata: 27 nTPM
amygdala: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 1.51

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WWC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WWC3 as an antibody target. Whether an autoantibody or antibody against WWC3 could matter depends on whether native WWC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WWC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WWC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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