Seroatlas · Human Serome Atlas

SMURF2

E3 ubiquitin-protein ligase SMURF2

Also known as: SMUF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HAU4
Gene
SMURF2
Ensembl
ENSG00000108854
Chromosome
17
Canonical length
748 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Enables SMAD binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent protein catabolic process. Located in nuclear speck. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

748 residues, UniProt reviewed canonical sequence.

>Q9HAU4|SMURF2
     1  MSNPGGRRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK
    61  WNQHYDLYIG KSDSVTISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL
   121  GPNDNDTVRG QIVVSLQSRD RIGTGGQVVD CSRLFDNDLP DGWEERRTAS GRIQYLNHIT
   181  RTTQWERPTR PASEYSSPGR PLSCFVDENT PISGTNGATC GQSSDPRLAE RRVRSQRHRN
   241  YMSRTHLHTP PDLPEGYEQR TTQQGQVYFL HTQTGVSTWH DPRVPRDLSN INCEELGPLP
   301  PGWEIRNTAT GRVYFVDHNN RTTQFTDPRL SANLHLVLNR QNQLKDQQQQ QVVSLCPDDT
   361  ECLTVPRYKR DLVQKLKILR QELSQQQPQA GHCRIEVSRE EIFEESYRQV MKMRPKDLWK
   421  RLMIKFRGEE GLDYGGVARE WLYLLSHEML NPYYGLFQYS RDDIYTLQIN PDSAVNPEHL
   481  SYFHFVGRIM GMAVFHGHYI DGGFTLPFYK QLLGKSITLD DMELVDPDLH NSLVWILEND
   541  ITGVLDHTFC VEHNAYGEII QHELKPNGKS IPVNEENKKE YVRLYVNWRF LRGIEAQFLA
   601  LQKGFNEVIP QHLLKTFDEK ELELIICGLG KIDVNDWKVN TRLKHCTPDS NIVKWFWKAV
   661  EFFDEERRAR LLQFVTGSSR VPLQGFKALQ GAAGPRLFTI HQIDACTNNL PKAHTCFNRI
   721  DIPPYESYEK LYEKLLTAIE ETCGFAVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SMURF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 13 nTPM
  • testis: 12 nTPM
  • retina: 12 nTPM
  • lung: 9.9 nTPM
  • small intestine: 9.5 nTPM
  • thyroid gland: 7.7 nTPM

Single-cell type

  • enterocytes: 509 nCPM
  • thymocytes: 446 nCPM
  • microglia: 334 nCPM
  • fibro-adipogenic progenitors: 323 nCPM
  • pituicytes/fscs: 279 nCPM
  • neutrophils: 266 nCPM

Immune cell

  • NK-cell: 2.7 nTPM
  • eosinophil: 1.5 nTPM
  • neutrophil: 1.4 nTPM
  • memory CD8 T-cell: 1.2 nTPM
  • gdT-cell: 1.1 nTPM
  • MAIT T-cell: 1.1 nTPM

Brain region

  • cerebellum: 21 nTPM
  • medulla oblongata: 20 nTPM
  • basal ganglia: 18 nTPM
  • cerebral cortex: 18 nTPM
  • hypothalamus: 18 nTPM
  • white matter: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.87
gnomAD missense Z
2.9
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SMURF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SMURF2 as an antibody target. Whether an autoantibody or antibody against SMURF2 could matter depends on whether native SMURF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SMURF2 is annotated at the cell surface, where native SMURF2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SMURF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SMURF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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